Mucin phenotypic expression and background mucosa of esophagogastric junctional adenocarcinoma
Mucin phenotypic expression and background mucosa of esophagogastric junctional adenocarcinoma
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DOI：
10.1007/s10120-004-0275-6
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发表时间：
2004-06
期刊：
影响因子：
7.4
通讯作者：
N. Tsuji;S. Ishiguro;Y. Tsukamoto;M. Mano;T. Kasugai;I. Miyashiro;Y. Doki;H. Iishi;M. Kudo
中科院分区：
文献类型：
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作者：
N. Tsuji;S. Ishiguro;Y. Tsukamoto;M. Mano;T. Kasugai;I. Miyashiro;Y. Doki;H. Iishi;M. Kudo
背景在西方，贲门或食管胃交界处（EGJ）腺癌的发病率正在增加。然而，这种癌有不同的定义，它包含异质性肿瘤。在日本，这种癌的频率是低的，鲜为人知的是it.We研究了小食管胃交界腺癌，以确定其特点在日本patients.MethodsFifty 4 Siewert II型交界腺癌（肿瘤直径最大为4cm）进行了研究。肿瘤分为两种类型：跨越EGJ的肿瘤（EGJ型）和完全发生在EGJ下方的肿瘤（bEGJ型）。评价肿瘤及周围粘膜的特征。粘蛋白，p53过表达，和幽门螺杆菌感染的表型表达进行了研究组织学和p53 chemical.Results23例（43%）患者有EGJ型和31例（57%）有bEGJ型癌。EGJ型中晚期癌的比例明显较高。组间在组织学类型、粘蛋白表型和p53蛋白过表达方面存在一定的相似性和差异性，但无统计学意义。在EGJ型肿瘤周围的粘膜中，与bEGJ型肿瘤相比，泌酸腺的保存明显更好，胃肠上皮化生的发生率明显更低，H。幽门感染率较低。Barrett's化生仅见于2例，EGJ型。结论EGJ型和bEGJ型腺癌有不同的背景胃粘膜。EGJ型胃泌酸腺萎缩较少，胃内肠上皮化生较少。这种类型似乎是西方型交界腺癌，在日本仍然很少见。在日本，许多晚期的交界腺癌都是起源于交界区。
BackgroundIn the West, the incidence of adenocarcinoma of the cardia or esophagogastric junction (EGJ) is increasing. This carcinoma is variously defined, however, and it contains heterogeneous tumors. In Japan, the frequency of this carcinoma is low, and little is known about it. We studied small esophagogastric junctional adenocarcinoma to determine its characteristics in Japanese patients.MethodsFifty-four patients with Siewert type II junctional adenocarcinoma (with tumors ≪4 cm in maximum diameter) were studied. The carcinomas were classified into two types: tumors straddling the EGJ (EGJ-type) and tumors occurring entirely below the EGJ (bEGJ-type). Characteristics of the tumors and surrounding mucosae were evaluated. Phenotypic expression of mucin, p53 overexpression, andHelicobacter pyloriinfection were investigated histologically and immunohistochemically.ResultsTwenty-three (43%) patients had EGJ-type and 31 (57%) had bEGJ-type carcinomas. The ratio of advanced cancers was significantly higher in EGJ-type. Some between-group similarities and differences existed in histological type, mucin phenotype, and p53 protein overexpression, but they were not statistically significant. In the mucosa surrounding EGJ-type tumors vs bEGJ-type tumors, oxyntic glands were significantly better preserved, gastric intestinal metaplasia occurred significantly less frequently, and theH. pyloriinfection rate was lower. Barrett’s metaplasia was seen in only 2 patients, with the EGJ-type.ConclusionEGJ-type and bEGJ-type adenocarcinomas have different background mucosa of the stomach. EGJ-type has less atrophy of the oxyntic glands and less intestinal metaplasia in the stomach. This type appears to be the Western-type junctional adenocarcinoma that is still rare in Japan. Many cases of advanced junctional adenocarcinoma in Japan are of subjunctional origin.