Understanding the role of ETS-mediated gene regulation in complex biological processes.
Understanding the role of ETS-mediated gene regulation in complex biological processes.
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DOI：
10.1016/b978-0-12-407190-2.00001-0
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发表时间：
2013
影响因子：
--
通讯作者：
Watson, Dennis K.
中科院分区：
文献类型：
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作者：
Findlay, Victoria J.;LaRue, Amanda C.;Turner, David P.;Watson, Patricia M.;Watson, Dennis K.
Ets因子是进化上保守的转录因子的最大家族之一的成员，调节正常细胞稳态中的关键功能，当受到干扰时，其有助于肿瘤进展。在癌症进展过程中ETS因子表达和功能的充分记录的改变导致多效性效应，其表现为对靶基因的下游效应。多个ETS因子与靶基因上存在的相同调控位点结合，表明冗余或竞争性功能。通过检查特定的ETS调控网络获得的抗转移和促转移特征将显着提高我们准确预测肿瘤进展的能力，并促进我们对癌症基因调控的理解。多个ETS基因功能的协调也介导肿瘤和基质细胞之间的相互作用，从而有助于癌症表型。因此，这些新的见解可能会提供一个新的观点ETS基因家族，以及研究复杂的生物控制参与肿瘤进展的焦点。分子生物学的目标之一是阐明有助于癌症发展和进展的机制。对癌症分子基础的这种理解将为以下方面提供新的可能性：（1）早期检测以及更好的疾病诊断和分期;（2）检测微小残留疾病复发并评估对治疗的反应;（3）预防;以及（4）新的治疗策略。对ETS调节的生物学途径的了解将直接影响这些领域。
Ets factors are members of one of the largest families of evolutionarily conserved transcription factors, regulating critical functions in normal cell homeostasis, which when perturbed contribute to tumor progression. The well-documented alterations in ETS factor expression and function during cancer progression result in pleiotropic effects manifested by the downstream effect on their target genes. Multiple ETS factors bind to the same regulatory sites present on target genes, suggesting redundant or competitive functions. The anti- and prometastatic signatures obtained by examining specific ETS regulatory networks will significantly improve our ability to accurately predict tumor progression and advance our understanding of gene regulation in cancer. Coordination of multiple ETS gene functions also mediates interactions between tumor and stromal cells and thus contributes to the cancer phenotype. As such, these new insights may provide a novel view of the ETS gene family as well as a focal point for studying the complex biological control involved in tumor progression. One of the goals of molecular biology is to elucidate the mechanisms that contribute to the development and progression of cancer. Such an understanding of the molecular basis of cancer will provide new possibilities for: (1) earlier detection, as well as better diagnosis and staging of disease; (2) detection of minimal residual disease recurrences and evaluation of response to therapy; (3) prevention; and (4) novel treatment strategies. Increased understanding of ETS-regulated biological pathways will directly impact these areas.