Latent infection and the elusive cytomegalovirus.
Latent infection and the elusive cytomegalovirus.
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潜伏感染和难以捉摸的巨细胞病毒。
DOI：
--
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发表时间：
1983
期刊：
影响因子：
--
通讯作者：
M. Jordan
中科院分区：
文献类型：
--
作者：
M. Jordan
疱疹病毒的特点是在宿主中建立潜伏感染。在某些情况下，通过实验确定了含有休眠病毒的组织部位，甚至是特定的细胞。然而，尽管流行病学证据表明，在输血或移植器官中，未检测到的病毒可以从供者转移到接受者，但在人类中，巨细胞病毒(CMV)潜伏期的位置很难通过实验确定。近年来，用杂交法在外周血白细胞和正常或恶性结肠组织中发现了人巨细胞病毒DNA。对小鼠的研究强烈表明，脾B淋巴细胞是潜伏的CMV的细胞库；然而，该病毒也可能在唾液腺、前列腺、睾丸、外周血以及可能的巨噬细胞中持续存在。这些组织中潜伏的CMV感染是以单一的普遍存在的细胞类型(如淋巴细胞或巨噬细胞)还是在各种细胞类型中保持尚不清楚。明确与CMV潜伏感染相关的部位和机制，对于深入了解CMV感染的发病机制是至关重要的。现在已经开始了巨细胞病毒活疫苗的试验，显然需要对人类和动物模型中潜在的巨细胞病毒感染进行进一步的研究。
Herpesviruses characteristically establish latent infections in their hosts. In some instances, the tissue sites or even the specific cells that harbor dormant virus have been identified experimentally. However, the sites of cytomegalovirus (CMV) latency have been difficult to define experimentally in humans, even though epidemiologic evidence indicates that undetectable virus can be transferred from donor to recipient in transfused blood or a transplanted organ. Recently, DNA of human CMV has been found in peripheral blood leukocytes and in normal or malignant colonic tissue by hybridization methods. Studies in mice strongly implicate splenic B lymphocytes as cellular reservoirs of latent CMV; however, the virus may also persist in the salivary glands, the prostate, the testes, peripheral blood, and possibly macrophages. Whether latent CMV infection in these tissues is maintained in a single ubiquitous cell type (e.g., lymphocytes or macrophages) or in various cell types is not known. Definition of the sites and mechanisms involved in the maintenance of latent CMV is essential for a thorough understanding of the pathogenesis of CMV infection. Now that trials with live CMV vaccine have begun, further investigations of latent CMV infection in humans and in animal models are clearly needed.
白血病重新激活小鼠巨细胞病毒。
DOI：
10.1099/0022-1317-51-2-401
发表时间：
1980
期刊：
The Journal of general virology
影响因子：
--
作者：
Mayo,DR;Rapp,F
通讯作者：
Rapp,F
与白细胞输注相关的巨细胞病毒感染。
影响因子：
39.2
作者：
Winston,DJ;Ho,WG;Howell,CL;Miller,MJ;Mickey,R;Martin,WJ;Lin,CH;Gale,RP
通讯作者：
Gale,RP