Frequency of IL-10-producing regulatory B cells associated with disease activity in thyroid-associated orbitopathy
Frequency of IL-10-producing regulatory B cells associated with disease activity in thyroid-associated orbitopathy
复制标题
甲状腺相关性眼病中产生 IL-10 的调节性 B 细胞的频率与疾病活动相关
DOI：
10.18240/ijo.2018.09.05
复制
发表时间：
2018-09-18
影响因子：
1.4
通讯作者：
Yang, Hua-Sheng
中科院分区：
文献类型：
--
作者：
Ding, Yun-Gang;Chen, Guo;Yang, Hua-Sheng
目的：目的探讨白细胞介素10（IL-10）分泌调节性B（B10）细胞与甲状腺相关性眼眶病（TAO）临床特征的关系。从30例TAO患者和16例健康对照者的血液样品中分离外周血单个核细胞（PBMC），并用CD 40配体和CpG刺激48小时。结果：TAO患者IL-10（+）B细胞在CD 19（+）B细胞中的比例显著低于健康对照组（TAO：4.66%+/-1.88%vs健康对照组：4.66%+/-1.88%。6.82%+/-2.40%，P
AIM: To investigate the association between IL-10-producing regulatory B (B10) cells and the clinical features of thyroid-associated orbitopathy (TAO).METHODS: A total of 30 patients with TAO were recruited at Zhongshan Ophthalmic Center from May 2015 to December 2015. Peripheral blood mononuclear cells (PBMCs) were separated from blood samples of 30 TAO patients and 16 healthy controls and stimulated with CD40 ligand and CpG for 48h. The frequency of IL-10(+) B cells was examined by flow cytometry and the correlation between the frequency of IL-10(+) B cells and clinical features of TAO was analyzed by SPSS.RESULTS: The frequency of IL-10(+) B cells among CD19(+) B cells in TAO patients was significantly lower than in healthy controls (TAO: 4.66%+/- 1.88% vs healthy control: 6.82%+/- 2.40%, P