Emotional distress in chronic hepatitis C patients not receiving antiviral therapy
Emotional distress in chronic hepatitis C patients not receiving antiviral therapy
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DOI：
10.1016/s0168-8278(01)00280-x
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发表时间：
2002-03-01
影响因子：
25.7
通讯作者：
Lok, ASF
中科院分区：
文献类型：
--
作者：
Fontana, RJ;Hussain, KB;Lok, ASF
背景/目标：本研究的目的是确定一个大的连续的慢性丙型肝炎（CHC）患者不接受抗病毒therapy.Methods的患病率，类型和情绪困扰的严重程度：简明症状量表和67项问卷与SF-36嵌入其中，被用来研究220补偿CHC门诊患者。77例（35%）受试者报告总体严重程度指数（GSI）T评分显著升高，而人群对照组的预期频率为10%。此外，28-40%的受试者报告抑郁、焦虑、躯体化、精神病性和强迫症子量表T评分显著升高。有活动性精神病共病的受试者与有活动性医学共病的受试者和无医学或精神病共病的受试者相比，GSI和子量表T评分显著较高（P < 0.01）。然而，与人群对照组相比，单独患有CHC的患者也具有更高的GSI T评分升高频率（20%对10%）。GSI和子量表T评分与SF-36总评分密切相关（P < 0.001）。结论：35%未接受抗病毒治疗的CHC患者报告有临床显著的情绪困扰。除抑郁症外，还观察到一系列广泛的心理症状。对慢性丙型肝炎患者情绪困扰的发病机制和治疗还需进一步研究。(C)2002年欧洲肝脏研究协会。由Elsevier Science B. V.出版，版权所有。
Background/Aims: The aim of our study was to determine the prevalence, type, and severity of emotional distress in a large group of consecutive chronic hepatitis C (CHC) patients not receiving anti-viral therapy.Methods: The brief symptom inventory and a 67-item questionnaire with the SF-36 embedded within it were used to study 220 outpatients with compensated CHC.Results: Seventy-seven (35%) participants reported significantly elevated global severity index (GSI) T-scores compared to an expected frequency of 10% in population controls. In addition, significantly elevated depression, anxiety, somatization, psychoticism, and obsessive-compulsive subscale T-scores were reported in 28-40% of subjects. Subjects with an active psychiatric co-morbidity had significantly higher GSI and subscale T-scores compared to subjects with active medical co-morbidities and subjects without medical or psychiatric co-morbidities (P < 0.01). However, patients with CHC alone also had a higher frequency of elevated GSI T-scores compared to population controls (20 versus 10%). GSI and subscale T-scores were strongly associated with SF-36 summary scores (P < 0.001).Conclusions: Clinically significant emotional distress was reported in 35% of CHC patients not receiving antiviral therapy. In addition to depression, a broad array of psychological symptoms were observed. Further investigation into the etiopathogenesis and treatment of emotional distress in CHC patients is warranted. (C) 2002 European Association for the Study of the Liver. Published by Elsevier Science B.V. All rights reserved.