Hypoxia-inducible factors and kidney vascular development
Hypoxia-inducible factors and kidney vascular development
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DOI：
10.1097/01.asn.0000092794.37534.01
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发表时间：
2003-11-01
影响因子：
13.6
通讯作者：
Abrahamson, DR
中科院分区：
文献类型：
--
作者：
Freeburg, PB;Abrahamson, DR
在由缺氧诱导因子（HIF）强烈诱导并在肾微血管发育期间高度表达的基因中，血管内皮生长因子编码对胚胎血管发生和血管生成至关重要的有效内皮有丝分裂原和化学引诱物。在发育中的肾脏中，肾小球足细胞是血管内皮生长因子的特别丰富的来源，其可能用于将内皮前体吸引到未成熟肾小球的血管裂隙中，促进其有丝分裂和分化成肾小球内皮细胞，并通过成熟协助维持其高度分化的状态。本文综述了HIF的结构、功能和表达，并对肾血管发育过程中HIF靶基因的表达进行了讨论。此外，据推测，不同的HIF异源二聚体在不同的细胞群体中是稳定的，这可能导致细胞选择性诱导HIF靶基因对肾血管发生/血管生成很重要。
Among the genes strongly induced by hypoxia-inducible factors (HIF) and highly expressed during kidney microvascular development is vascular endothelial growth factor, which encodes a potent endothelial mitogen and chemoattractant critical for embryonic vasculogenesis and angiogenesis. In developing kidney, glomerular podocytes are particularly rich sources of vascular endothelial growth factor, which probably serves to attract endothelial precursors into vascular clefts of immature glomeruli, promote their mitosis and differentiation into glomerular endothelial cells, and assist with maintenance of their highly differentiated state through maturation. This article summarizes the structure, function, and expression of HIF and discusses HIF target genes expressed during kidney vascular development. Furthermore, it is speculated that different HIF heterodimers are stabilized in different cell populations, which may lead to cell-selective induction of HIF target genes important for renal vasculogenesis/angiogenesis.