Relationship between Serum Inflammatory Marker and Bone Mineral Density in Healthy Adults.
Relationship between Serum Inflammatory Marker and Bone Mineral Density in Healthy Adults.
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DOI：
10.11005/jbm.2016.23.1.27
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发表时间：
2016-02
影响因子：
--
通讯作者：
Kim SK
中科院分区：
文献类型：
--
作者：
Lim HS;Park YH;Kim SK
炎症标记物已被证明在骨重塑中发挥重要作用。本研究的目的是探讨健康成人血清C反应蛋白（CRP）、脂联素、肿瘤坏死因子-α（TNF-α）与骨骼健康之间的关系。我们测量了 76 名成年人的血清 CRP、脂联素、TNF-α 水平以及腰椎和股骨颈骨矿物质密度 (BMD)。对参与者进行了人体测量和营养摄入调查。参与者被分为两组（BMD正常组=40；52.6%，BMD下降组=36；47.4%）。 BMD 降低组的 CRP 浓度显着较高。 BMD降低组的脂联素浓度较低，但差异不显着。 BMD降低组TNF-α浓度较高，但差异不显着。研究发现骨密度降低组的参与者钙摄入量较低。 BMD降低组的钠摄入量明显更高。 BMD 降低组的 BMD 与 CRP 和膳食钠摄入量呈负相关。血清 CRP 和膳食钠摄入量与 BMD 相关。需要进一步的研究来确认炎症标记物在调节骨骼影响方面的潜在作用。
Inflammatory markers have been shown to play an important role in bone remodeling. The purpose of this study was to investigate the relationship among serum C-reactive protein (CRP), adiponectin, tumor necrosis factor-alpha (TNF-α) and bone health in healthy adults. We measured serum levels of CRP, adiponectin, TNF-α as well as lumbar spine and femoral neck bone mineral density (BMD) in 76 adults. Anthropometric measurements and nutrient intake survey of participants were carried out. The participants were divided into two groups (normal BMD group=40; 52.6%, decreased BMD group=36; 47.4%). The CRP concentration was significantly higher in the decreased BMD group. The adiponectin concentration was lower in the decreased BMD group but the difference was not significant. The TNF-α concentration was higher in the decreased BMD group, the difference was not significant. The participants in the decreased BMD group were found to have lower calcium intakes. The sodium intake of the decreased BMD group was significantly higher. The BMD in the decreased BMD group showed inverse correlations with CRP and dietary sodium intake. Serum CRP and dietary sodium intake is associated with BMD. Further research is needed to confirm the potential role of inflammatory marker to modulate the effects on bone.