Reporting of atypical squamous cells, cannot exclude a high‐grade squamous intraepithelial lesion (ASC‐H) on cervical samples: Is it significant?
Reporting of atypical squamous cells, cannot exclude a high‐grade squamous intraepithelial lesion (ASC‐H) on cervical samples: Is it significant?
复制标题
报告非典型鳞状细胞，不能排除宫颈样本中的高级鳞状上皮内病变（ASC-H）：是否重要？
作者：
S. Selvaggi
“非典型鳞状细胞，不能排除高度鳞状上皮内病变（ASC-H）”是2001年Bethesda宫颈细胞学命名系统中的一个新诊断类别。这项为期7个月的回顾性研究（2002年3月1日至2002年9月30日）旨在评价ASC‐H对宫颈Thin Prep® Pap Tests™的意义。在此期间，9，214例巴氏试验中有25例（0.27%）被诊断为ASC-H，其中22例导致随访宫颈活检和/或宫颈锥，这构成了本研究的基础。22例组织标本中，5例（23%）阴性，17例（77%）阳性。在阳性标本中，有2例（12%）低度鳞状上皮内病变（LSIL）和15例（88%）高度鳞状上皮内病变（HSIL）。在22例病例中，ASC-H诊断包括19例（86%）病例中的不成熟/非典型鳞状上皮化生与鳞状上皮内病变（SIL），以及3例（14%）病例中的高核质比小细胞紧密簇。本研究的结果表明，宫颈样本中ASC-H的报告确实导致在大量病例中检出HSIL（本研究中为68%）。因此，需要对患者进行进一步评估。细胞病理学诊断。2003;29：38-41.© 2003 Wiley利斯公司
“Atypical squamous cells, cannot exclude a high‐grade squamous intraepithelial lesion (ASC‐H)” is a new diagnostic category in the 2001 Bethesda nomenclature system for cervical cytology. The purpose of this 7‐mo retrospective study (March 1, 2002–September 30, 2002) was to evaluate the significance of ASC‐H on cervical Thin Prep® Pap Tests™. During this period, 25 (0.27%) of 9,214 Pap Tests were diagnosed as ASC‐H, 22 of which resulted in either follow‐up cervical biopsies and/or cervical cones, and which formed the basis of this study. Tissue specimens (22 cases) were negative in 5 cases (23%) and positive in 17 cases (77%). Of the positive specimens, there were 2 (12%) low‐grade squamous intraepithelial lesions (LSIL) and 15 (88%) high‐grade squamous intraepithelial lesions (HSIL). Of the 22 cases, ASC‐H diagnoses included immature/atypical squamous metaplasia vs. a squamous intraepithelial lesion (SIL) in 19 (86%) cases, and tight clusters of small cells with a high nuclear to cytoplasmic ratio in 3 (14%) cases. The results of this study indicate that the reporting of ASC‐H on cervical samples does lead to the detection of HSILs in a significant number of cases (68% in this study). Therefore, further evaluation of the patient is warranted. Diagn. Cytopathol. 2003;29:38–41. © 2003 Wiley‐Liss, Inc.
“ASCUS，排除 HSIL”：细胞学特征、组织学相关性和人乳头瘤病毒检测。
DOI：
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发表时间：
1999
期刊：
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
影响因子：
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作者：
Sherman,ME;Tabbara,SO;Scott,DR;Kurman,RJ;Glass,AG;Manos,MM;Burk,RD;Rush,BB;Schiffman,M
通讯作者：
Schiffman,M