Dynamics of viral load in plasma and HIV DNA in lymphocytes during highly active antiretroviral therapy (HAART): High viral burden in macrophages after 1 year of treatment
Dynamics of viral load in plasma and HIV DNA in lymphocytes during highly active antiretroviral therapy (HAART): High viral burden in macrophages after 1 year of treatment
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DOI：
10.1179/joc.2001.13.2.188
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发表时间：
2001-04-01
影响因子：
1.8
通讯作者：
Benedetto, A
中科院分区：
文献类型：
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作者：
Garbuglia, AR;Zaccarelli, M;Benedetto, A
在这项研究中，我们评估了血浆中HIV RNA和外周血细胞中HIV DNA的水平。这项研究包括16名有抗逆转录病毒经验的HIV患者，他们的免疫功能严重受到抑制。第一个月后，56.2%的患者检测不到HIV RNA水平，这一比例在一年后保持稳定(53.3%)。在登记时，7名(43.7%)CD4+T细胞计数低(平均每毫米22(3)比73)的患者淋巴细胞中HIV DNA水平低于检测限值(5拷贝/10(5))。他们随后都出现了HIV DNA的升高，在治疗的第一个月和第三个月之间可以检测到，与CD4+T细胞计数增加(平均22到95/mm(3))有关；在这些患者中，有4人这种增加是暂时的，一年后再次检测不到。在登记时可检测到HIV DNA的8名患者中，有7名患者的HIV DNA水平随着时间的推移而下降，15名患者中有7名(46.7%)在1年时血浆中未检测到HIV RNA水平，以及淋巴细胞中未检测到HIV DNA水平(P
In this study we evaluated the level of HIV RNA in plasma and HIV DNA in peripheral blood cells. Sixteen antiretroviral-experienced HIV patients with severe immune suppression were included in the study. After the first month, 56.2% of the patients showed undetectable levels of HIV RNA, this percentage remaining stable after 1 year (53.3%). At enrollment, 7 patients (43.7%) with a low CD4+T cell count (mean 22 per mm(3) versus 73) showed HIV DNA levels below the limit of detection (5 copies/10(5)) in lymphocytes. They all subsequently had increased HIV DNA that became detectable between the first and the third month of therapy, associated with an increase of the CD4+T cell count (mean 22 to 95 / mm(3)); in 4 of these patients this increase was transitory, becoming undetectable again after one year. In 7 out of the 8 patients with detectable HIV DNA at enrollment, the HIV DNA level decreased over time, Seven out of 15 patients at 1 year (46.7%) showed both undetectable levels of HIV RNA in plasma and HIV DNA in lymphocytes (p