Maternal poly I:C exposure during pregnancy regulates TNFα BDNF, and NGF expression in neonatal brain and the maternal-fetal unit of the rat
Maternal poly I:C exposure during pregnancy regulates TNFα BDNF, and NGF expression in neonatal brain and the maternal-fetal unit of the rat
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DOI：
10.1016/j.jneuroim.2004.10.008
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发表时间：
2005-02-01
影响因子：
3.3
通讯作者：
Vadlamudi, S
中科院分区：
文献类型：
--
作者：
Gilmore, JH;Jarskog, LF;Vadlamudi, S
妊娠期母体感染与神经发育障碍风险增加有关。给予大鼠多核糖素-多核糖素二酸（聚I:C）或生理盐水模拟母体感染；ELISA法检测TNFalpha、脑源性神经营养因子（BDNF）、神经生长因子（NGF）水平。TNFalpha在母体血浆、胎盘和羊水中显著升高，而在胎儿肝脏/脾脏和新生儿大脑中显著降低。胎盘和胎儿肝/脾中NGF和BDNF显著减少。胎儿或新生儿大脑中BDNF或NGF没有变化。母体暴露于聚I:C后，TNFalpha、BDNF和NGF的变化代表了母体感染增加神经发育障碍风险的潜在机制。(C) 2004 Elsevier B.V.版权所有
Maternal infection during pregnancy is associated with increased risk for neurodevelopmental disorders. Polyriboinosinic-polyribocytidilic acid (poly I:C) or saline was administered to rats to model maternal infection; levels of TNFalpha, brain-derived neurotrophic factor (BDNF), and nerve growth factor (NGF) were determined by ELISA. TNFalpha was significantly increased in maternal plasma, placenta, and amniotic fluid, while it was significantly decreased in fetal liver/spleen and neonatal brain. NGF and BDNF were significantly decreased in the placenta and fetal liver/spleen. There was no change in BDNF or NGF in the fetal or neonatal brain. Changes in TNFalpha, BDNF, and NGF after maternal exposure to poly I:C represent a potential mechanism through which maternal infection increases risk for neurodevelopmental disorders. (C) 2004 Elsevier B.V. All rights reserved.