Dendrimer design using CuI-catalyzed alkyne-azide "click-chemistry"
Dendrimer design using CuI-catalyzed alkyne-azide "click-chemistry"
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DOI：
10.1039/b809870k
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发表时间：
2008-01-01
影响因子：
4.9
通讯作者：
Kakkar, Ashok
中科院分区：
文献类型：
--
作者：
Franc, Gregory;Kakkar, Ashok
由Cu-1催化的叠氮化物与炔的化学选择性[3+2]环加成反应已被称为“点击化学”。该反应可以容易地进行，并且不需要进一步纯化就可以形成纯产物，这为开发具有不同性质的单分散1，4-二取代的1，2，3-三唑杂环基大分子提供了巨大的潜力。这种方法在设计树枝状聚合物或在外围用所需分子对其进行功能化方面的多功能性重新点燃了开发纳米材料的希望，其规模可以加速其进入工业用途。
The chemoselective [3+2] cycloaddition of an azide on to an alkyne, catalyzed by Cu-1, has become known as "click-chemistry''. The ease with which this reaction can be carried out and the formation of pure product without the need for further purification, offer a tremendous potential in developing monodisperse 1,4-disubstituted 1,2,3-triazole heterocycle based macromolecules of a diverse nature. The versatility of this approach in designing dendrimers or functionalizing them at the periphery with desired molecules has rekindled hopes in developing nanomaterials, at scales that can accelerate their entry into industrial usage.