Birch pollen-related food as a provocation factor of allergic symptoms in children with atopic eczema/dermatitis syndrome
Birch pollen-related food as a provocation factor of allergic symptoms in children with atopic eczema/dermatitis syndrome
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DOI：
10.1111/j.1398-9995.2004.00493.x
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发表时间：
2004-09-01
期刊：
影响因子：
12.4
通讯作者：
Werfel, T
中科院分区：
文献类型：
--
作者：
Breuer, K;Wulf, A;Werfel, T
背景资料：对牛奶或鸡蛋的食物过敏是患有特应性湿疹/皮炎综合征（AEDS）的儿童的常见问题，但桦树花粉相关食物在诱发过敏症状中的作用仍不清楚。患者/方法：十二个孩子（中位年龄5岁）与AEDS进行了口服挑战与桦树花粉相关的食物，据报道，诱导没有立即症状，但却经常食用总IgE和特异性IgE的桦树花粉，Bet V 12和各种桦树花粉相关的foods.Results：7的12名儿童表现出即时和/或迟发湿疹反应后，摄入桦树花粉相关的食品。4名儿童在口服激发后24小时湿疹恶化，激发前后SCORAD有显著差异。有没有差异，总IgE或桦树花粉特异性IgE的儿童与迟发湿疹反应和非反应children.Conclusions：桦树花粉相关的食物可能会引起过敏症状的儿童AEDS谁表现出致敏桦树花粉。口服激发试验应在那些患有严重AEDS和对桦树花粉过敏原高度敏感的儿童中进行，即使没有食物过敏史。
Background: Food allergy to cow's milk or hen's egg is a common problem in children with atopic eczema/dermatitis syndrome (AEDS) but the role of birch pollen-related food for the induction of allergic symptoms is still not clear.Patients/methods: Twelve children (median age 5 years) with AEDS underwent an oral challenge with those birch pollen-related foods which were reported to induce no immediate symptoms, but were consumed on a regular basis. Total IgE and specific IgE to birch pollen, Bet v 1/2 and various birch pollen-related foods were determined.Results: Seven of 12 children showed immediate and/or late eczematous reactions upon ingestion of birch pollen-related foodstuff. Four children showed a worsening of eczema 24 h upon oral challenge with a significant difference in SCORAD before and after challenge. There were no differences in terms of total IgE or birch pollen-specific IgE between children with a late eczematous response and non-reacting children.Conclusions: Birch pollen-related food may induce allergic symptoms in children with AEDS who exhibit a sensitization to birch pollen. Oral challenge tests should be performed in those children who suffer from severe AEDS and who are highly sensitized to birch pollen allergens even in the absence of a history suggestive of food allergy.