Depression and self-medication with nicotine: The modifying influence of the dopamine D4 receptor gene
Depression and self-medication with nicotine: The modifying influence of the dopamine D4 receptor gene
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DOI：
10.1037/0278-6133.17.1.56
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发表时间：
1998-01-01
影响因子：
4.2
通讯作者：
Shields, PG
中科院分区：
文献类型：
--
作者：
Lerman, C;Caporaso, N;Shields, PG
这项研究评估了是否有遗传亚组的抑郁症患者或多或少倾向于从事自我药疗吸烟的做法。吸烟者（N = 231）完成了抑郁和吸烟习惯的自我报告问卷，并对多巴胺D4受体（DRD4）基因进行了基因分型。一个显着的相互作用（DRD4基因型x抑郁症）被发现刺激吸烟和消极影响减少吸烟。具体来说，这些吸烟行为显着提高抑郁症吸烟者的DRD4的短等位基因纯合子，但不是在那些杂合或纯合的DRD4的长等位基因。这些初步结果表明，吸烟的奖励作用和尼古丁替代疗法对抑郁吸烟者的有益作用可能部分取决于参与多巴胺传递的遗传因素。
This study evaluated whether there are genetic subgroups of depressed individuals who are more or less predisposed to engage in self-medication smoking practices. Smokers (N = 231) completed self-report questionnaires of depression and smoking practices and were genotyped for the dopamine D4 receptor (DRD4) gene. A significant interaction (DRD4 Genotype x Depression) was found for stimulation smoking and negative-affect reduction smoking. Specifically, these smoking practices were significantly heightened in depressed smokers homozygous for the short alleles of DRD4 but not in those heterozygous or homozygous for the long alleles of DRD4. These preliminary results suggest that the rewarding effects of smoking and the beneficial effects of nicotine replacement therapy for depressed smokers may depend, in part, on genetic factors involved in dopamine transmission.