Gradient expectations: Revisiting Charles Manning Child's theory of metabolic regionalisation in developmental patterning and regeneration.
Gradient expectations: Revisiting Charles Manning Child's theory of metabolic regionalisation in developmental patterning and regeneration.
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DOI：
10.1111/wrr.12998
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发表时间：
2022-11
影响因子：
2.9
通讯作者：
Wills, Andrea E.
中科院分区：
文献类型：
--
作者：
Patel, Jeet H.;Wills, Andrea E.
查尔斯·曼宁·蔡尔德（Charles Manning Child）介绍了几个早期模型之一，以解释生物体如何在胚胎发生和再生过程中建立和重建位置身份。在他的梯度理论模型中，沿着轴的组织沿着表现出代谢活性的分级水平，这通过它们对代谢抑制剂的不同敏感性来证明。虽然蔡尔德的工作在他那个时代很难放在一个机械的框架中，但技术的进步和最近在胚胎和再生生物体中的发现使他早期关于氧化还原信号的工作成为一个新的位置线索。图形摘要1：通过磁化率的梯度识别模型。将靶动物或组织，如真涡虫，暴露于靶向抑制剂。图中图示了抑制线粒体呼吸的氰化钾。定期测定坏死。早期死亡的组织（灰色）被认为具有更大的目标过程活性。在涡虫中，呼吸抑制首先导致前部结构的死亡，并且在更长的时间之后，后部结构死亡。这使得可以得出这样的结论，即线粒体呼吸存在2个梯度，一个更强的基于前向的梯度和一个更弱的基于后向的梯度。
Charles Manning Child introduced one of several early models to explain how an organism can both establish and reestablish positional identity during embryogenesis and regeneration. In his gradient theory model, tissues along an axis exhibit graded levels of metabolic activity, demonstrated through their differential susceptibility to metabolic inhibitors. While Child’s work was difficult to place in a mechanistic framework in his own time, technological advances and recent discoveries in both embryos and regenerating organisms make his early work on redox signaling as a positional cue newly pertinent. Graphical Abstract 1: Model of gradient identification via susceptibility. A target animal or tissue, such as a planaria, is exposed to a targeted inhibitor. Here, potassium cyanide, which inhibits mitochondrial respiration, is schematized. Necrosis is assayed periodically. Tissues which die early (gray) are considered to have greater activity of the targeted process. In planaria, inhibition of respiration first leads to death of anterior structures and, after more time has passed, posterior structures. This allows the conclusion that there are 2 gradients for mitochondrial respiration, a stronger anterior based gradient and a weaker posterior based one.
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DOI：
10.1073/pnas.1300290110
发表时间：
2013-06-04
影响因子：
11.1
作者：
Godwin, James W.;Pinto, Alexander R.;Rosenthal, Nadia A.
通讯作者：
Rosenthal, Nadia A.
影响因子：
2.9
作者：
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通讯作者：
Veraitch, Farlan S.
影响因子：
11.8
作者：
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通讯作者：
Aulehla A
影响因子：
10.5
作者：
Iyer, NV;Kotch, LE;Semenza, GL
通讯作者：
Semenza, GL
影响因子：
--
作者：
Hyman, LH
通讯作者：
Hyman, LH