Low brain-derived neurotrophic factor (BDNF) levels in serum of depressed patients probably results from lowered platelet BDNF release unrelated to platelet reactivity
Low brain-derived neurotrophic factor (BDNF) levels in serum of depressed patients probably results from lowered platelet BDNF release unrelated to platelet reactivity
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DOI：
10.1016/j.biopsych.2005.01.008
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发表时间：
2005-05-01
影响因子：
10.6
通讯作者：
Bertschy, G
中科院分区：
文献类型：
--
作者：
Karege, F;Bondolfi, G;Bertschy, G
背景：近期报道表明脑源性神经营养因子（BDNF）在精神疾病中起作用。据报道，重度抑郁症患者血清BDNF水平降低，但这种降低的原因尚未得到研究。本研究的目的是评估血液中的BDNF和一种血小板活化指数PF4。
方法：对43例未用药的重度抑郁症患者（27例女性，16例男性）和35例健康对照者（18例女性，17例男性）进行血浆、血清和血液中BDNF含量的评估。采用酶联免疫吸附测定法检测脑源性神经营养因子和PF4，并使用蒙哥马利 - 阿斯伯格抑郁评定量表评估抑郁的严重程度。
结果：与对照组相比，抑郁症患者的血清和血浆BDNF水平降低。在全血中，抑郁症患者与对照组相比BDNF水平无变化。重度抑郁症患者的血清/血液BDNF比值较低。与对照组相比，抑郁症患者的血浆PF4水平升高，但血清PF4水平未升高。
结论：我们的研究结果表明，血清或血浆BDNF的改变不是由于血液BDNF的变化，而可能与BDNF的释放机制有关。BDNF的分泌似乎与血小板反应性无关；因此可能涉及其他机制，需要进一步阐明。
Background: Recent reports have suggested a role for brain-derived neurotrophic factor (BDNF) in psychiatric disorders. Decreased serum BDNF levels have been reported in major depression, but the cause of this decrease has not yet been investigated. The goal of this study was to assess blood BDNF and a platelet activation index, PF4.Methods: Forty-three drug-free patients (27 female, 16 male) diagnosed with major depression and 35 healthy control subjects (18 female, 17 male) were assessed for plasma, serum, and blood BDNF content. Brain-derived neurotrophic factor and PF4 were assayed with enzyme-linked immunosorbent assay methods, and severity of depression was evaluated with the Montgomery-Asberg Depression Rating Scale.Results. Serum and plasma BDNF levels were decreased in depressed patients compared with control subjects. In whole blood, BDNF levels were unaltered in the depressed subjects compared with control subjects. The serum/blood BDNF ratio was lower inpatients with major depression. Increased plasma but not serum PF4 levels were observed in depressed subjects compared with control subjects.Conclusions. Our results suggest that an alteration of serum or plasma BDNF is not due to the change in blood BDNF but rather is probably related to mechanisms of BDNF release. Secretion of BDNF seems to be independent of platelet reactivity; other mechanisms are therefore probably involved and need to be elucidated.