Mammalian glycosylation in immunity.

Mammalian glycosylation in immunity.
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DOI:
10.1038/nri2417
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发表时间:
2008-11
期刊:
Nature reviews. Immunology
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其他
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糖基化产生多样化和丰富的聚糖,这些聚糖统称为糖类。聚糖是构成所有细胞的四大基本大分子成分之一,在免疫系统中受到高度调控。它们的多样性反映了它们的多种生物学功能,包括蛋白质受体的配体,即凝集素。自从发现选择素及其聚糖配体对白细胞运输的调节很重要以来,已经表明脊椎动物免疫系统的其他特征也受到内源性细胞糖基化的控制。本文综述了哺乳动物血糖在免疫学中的新作用。
Glycosylation produces a diverse and abundant repertoire of glycans, which are collectively known as the glycome. Glycans are one of the four fundamental macromolecular components of all cells, and are highly regulated in the immune system. Their diversity reflects their multiple biological functions that encompass ligands for proteinaceous of receptors known as lectins. Since the discovery that selectins and their glycan ligands are important for the regulation of leukocyte trafficking, it has been shown that additional features of the vertebrate immune system are also controlled by endogenous cellular glycosylation. This Review focuses on the emerging immunological roles of the mammalian glycome.
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