Early Changes in Puffing Intensity When Exclusively Using Open-Label Very Low Nicotine Content Cigarettes.
Early Changes in Puffing Intensity When Exclusively Using Open-Label Very Low Nicotine Content Cigarettes.
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单独使用开放标签尼古丁含量极低的香烟时吸烟强度的早期变化。
DOI：
10.1093/ntr/ntac118
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发表时间：
2022
期刊：
影响因子：
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通讯作者：
Carpenter,Matt
中科院分区：
文献类型：
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作者：
White,CassidyM;Watson,Clifford;BravoCardenas,Roberto;Ngac,Phuong;Valentin-Blasini,Liza;Blount,BenjaminC;Koopmeiners,JosephS;Denlinger-Apte,RachelL;Pacek,LaurenR;Benowitz,NealL;Hatsukami,DorothyK;Donny,EricC;Carpenter,Matt
为了减少香烟尼古丁含量，吸烟者可以尝试通过使用更多的香烟或以更大的强度抽吸单个香烟来进行补偿。这种行为在正常尼古丁含量（NNC）香烟不易获得的条件下尤其可能。目前的主题内，住宅研究调查是否增加了吸烟强度与非常低的尼古丁含量（VLNC）香烟的使用，相对于NNC香烟的使用，当没有其他尼古丁products.Aims and MethodsSixteen成年人每天吸烟完成两个四晚的酒店住宿在查尔斯顿，南卡罗来纳州（美国）在2018年期间，只有NNC或只有VLNC香烟可访问。我们收集了所有吸烟香烟的过滤嘴，并测量了沉积的茄尼醇，以估计每支香烟的口腔尼古丁释放量。这些估计值在每个24小时期间的参与者内和参与者之间取平均值。然后，我们比较了参与者吸烟VLNC和NNC香烟口级尼古丁的比例与吸烟机（当膨化强度是恒定的）所产生的比例。ResultsAverage mouth-level尼古丁的估计，从酒店住宿期间吸烟的香烟表明参与者膨化VLNC香烟的强度比NNC香烟在各自的24小时内。然而，这种影响随着时间的推移而减弱（p<0.001）。具体而言，VLNC膨化强度为40.0%（95% CI：29.9，53.0）第一阶段大于NNC膨化强度，16.1%（95%置信区间：6.9，26.0）在第四阶段更大。结论每支香烟的平均抽吸强度升高与专用VLNC香烟的使用，但是这种影响的程度在四天内下降。在没有其他尼古丁来源的环境中，每天吸烟的人最初可能试图通过以更大的强度抽吸单个香烟来补偿香烟尼古丁的减少。最终，从VLNC香烟中获得正常尼古丁摄入量所需的补偿性行为变化是剧烈和不现实的。因此，人们不太可能持续尝试弥补非常低的香烟尼古丁含量。
IntroductionIn response to reducing cigarette nicotine content, people who smoke could attempt to compensate by using more cigarettes or by puffing on individual cigarettes with greater intensity. Such behaviors may be especially likely under conditions where normal nicotine content (NNC) cigarettes are not readily accessible. The current within-subject, residential study investigated whether puffing intensity increased with very low nicotine content (VLNC) cigarette use, relative to NNC cigarette use, when no other nicotine products were available.Aims and MethodsSixteen adults who smoke daily completed two four-night hotel stays in Charleston, South Carolina (United States) in 2018 during which only NNC or only VLNC cigarettes were accessible. We collected the filters from all smoked cigarettes and measured the deposited solanesol to estimate mouth-level nicotine delivery per cigarette. These estimates were averaged within and across participants, per each 24-h period. We then compared the ratio of participant-smoked VLNC and NNC cigarette mouth-level nicotine with the ratio yielded by cigarette smoking machines (when puffing intensity is constant).ResultsAverage mouth-level nicotine estimates from cigarettes smoked during the hotel stays indicate participants puffed VLNC cigarettes with greater intensity than NNC cigarettes in each respective 24-h period. However, this effect diminished over time (p< .001). Specifically, VLNC puffing intensity was 40.0% (95% CI: 29.9, 53.0) greater than NNC puffing intensity in the first period, and 16.1% (95% CI: 6.9, 26.0) greater in the fourth period.ConclusionAverage puffing intensity per cigarette was elevated with exclusive VLNC cigarette use, but the extent of this effect declined across four days.ImplicationsIn an environment where no other sources of nicotine are available, people who smoke daily may initially attempt to compensate for cigarette nicotine reduction by puffing on individual cigarettes with greater intensity. Ultimately, the compensatory behavior changes required to achieve usual nicotine intake from VLNC cigarettes are drastic and unrealistic. Accordingly, people are unlikely to sustain attempts to compensate for very low cigarette nicotine content.