Triterpenoids and triterpenoid saponins from the aerial parts of Fagonia indica Burm
Triterpenoids and triterpenoid saponins from the aerial parts of Fagonia indica Burm
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DOI：
10.1016/j.phytol.2015.07.001
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发表时间：
2015-09-01
影响因子：
1.7
通讯作者：
Majeed, Saba
中科院分区：
文献类型：
--
作者：
Farheen, Rabia;Siddiqui, Bina Shaheen;Majeed, Saba
作为从本土药用植物中寻找新的生物活性化合物的一部分，我们对Fagonia indica Burm的地上部分进行了植物化学研究，从甲醇提取物中分离出7个化合物，其中包括2个新化合物，即indicacin(1)和fagonicin(2)，以及5个已知化合物（3-7）。化合物6和7至今未见报道。通过hrems、1D NMR （H-1、C-13 NMR和DEPT）和2D NMR （COSY、NOESY、HSQC和HMBC）的光谱数据，并与文献数据进行对比，对新化合物的结构进行了鉴定。研究了新化合物1和2对人结直肠癌细胞株H-29的细胞毒性。化合物1在6.25 μ M/mL剂量下表现出51.40%的细胞毒性，而化合物2在相同剂量下表现出39.3%的细胞毒性。(C) 2015年欧洲植物化学学会。Elsevier B.V.版权所有。
As part of our search of new bioactive compounds from indigenous medicinal plants, phytochemical investigation of the aerial parts of Fagonia indica Burm led to the isolation of seven compounds including two new compounds, namely, indicacin (1) and fagonicin (2), and five known compounds (3-7) from the methanol extract. Compounds 6 and 7 are hitherto unreported from this plant. The structures of the new compounds were elucidated from their spectral data, mainly HREIMS, 1D NMR (H-1, C-13 NMR, and DEPT) and 2D NMR (COSY, NOESY, HSQC and HMBC), and by comparison with the literature data. The new compounds 1 and 2 were assayed for their cytotoxicity against human colorectal cancer cell line H-29. Compound 1 exhibited 51.40% cytotoxicity at 6.25 mu M/mL dose whereas compound 2 demonstrated 39.3% cytotoxicity at the same dose. (C) 2015 Phytochemical Society of Europe. Published by Elsevier B.V. All rights reserved.