The trigger for PSE condition in stress-susceptible pigs.
The trigger for PSE condition in stress-susceptible pigs.
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应激敏感猪 PSE 状况的触发因素。
DOI：
10.1002/jsfa.2740271209
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发表时间：
1976
影响因子：
4.1
通讯作者：
A. Cheah
中科院分区：
文献类型：
--
作者：
K. S. Cheah;A. Cheah
不同品种猪背最长肌（LD）紧密偶联线粒体在厌氧过程中Ca2+外排速率存在差异。Ca2+的初始快速外排速率可以与猪的应激敏感性有关。应激易感猪（SS）和波兰-中国猪（SS） LD肌线粒体Ca2+外排的厌氧速率是应激抗性（SR）大白猪的两倍。杂交种（大白×马鞍背）的线粒体Ca2+外排率介于纯种SS和SR猪之间。氟烷只在SS猪体内提高Ca2+外排速率，而这种影响可以被MgCl2消除。SS猪和SR猪Ca2+外排速率的显著差异，以及氟烷仅在SS猪中增强Ca2+外排速率，为SS猪PSE（苍白、柔软和渗出）肌肉的形成和恶性高热提供了最终的解释。从SS猪线粒体中释放的过量Ca2+被认为是PSE肉的触发因素，也是恶性高热的情况。
Tightly coupled mitochondria from M. longissimus dorsi (LD) muscle of different breeds of pigs showed variations in the rate of Ca2+ efflux during anaerobiosis. The initial fast efflux rate of Ca2+ could be used to relate the stress-susceptibility of the pigs used. Mitochondria from LD muscle of stress-susceptible (SS) Pietrain and Poland China pigs showed an anaerobic rate of Ca2+ efflux twice that of stress-resistant (SR) Large Whites. Mitochondria from crossbreds (Large White x Saddleback) showed a Ca2+ efflux rate intermediate between that of purebred SS and SR pigs. Halothane enhanced the rate of Ca2+ efflux only in SS pigs, and this effect could be eliminated by MgCl2. The marked difference in the rate of Ca2+ efflux between SS and SR pigs, and the enhancement in the rate of Ca2+ efflux by halothane only in SS pigs, offers an ultimate explanation for the formation of PSE (pale, soft and exudative) muscle and malignant hyperthermia in SS pigs. The excess Ca2+ liberated from mitochondria of SS pigs is postulated to be the trigger for PSE meat and also the case of malignant hyperthermia.