Is the Ipsilateral Cortex Surrounding the Lesion or the Non-Injured Contralateral Cortex Important for Motor Recovery in Rats with Photochemically Induced Cortical Lesions?
Is the Ipsilateral Cortex Surrounding the Lesion or the Non-Injured Contralateral Cortex Important for Motor Recovery in Rats with Photochemically Induced Cortical Lesions?
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DOI：
10.1159/000095700
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发表时间：
2006-09
影响因子：
2.4
通讯作者：
K. Takata;H. Yamauchi;Hisashi Tatsuno;K. Hashimoto;M. Abo
中科院分区：
文献类型：
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作者：
K. Takata;H. Yamauchi;Hisashi Tatsuno;K. Hashimoto;M. Abo
主要目的：在光化学引发血栓形成（PIT）模型中，确定病变周围的同侧皮质或未损伤的对侧皮质对脑损伤后的运动恢复是否重要。研究设计：我们诱导PIT在感觉运动皮层的大鼠，并检查了运动功能的恢复，使用beam-walking test.Methods和程序：在24只大鼠，右感觉运动皮层损伤后2天的训练beam-walking测试（组1）。10天后，在左侧感觉运动皮层中诱导PIT。另外8只大鼠（第2组）接受2天的横梁行走训练，然后进行横梁行走试验以评估功能。测试10天后，左侧感觉运动皮层被损伤，并通过持续8天的横梁行走测试监测恢复。主要结局和结果：在第1组动物中，由右侧感觉运动皮层损伤引起的左后肢功能在术后10天内恢复。左侧病变引起的右后肢功能在6天内恢复。在第2组中，与双PIT模型一样，在总共12天的横梁行走训练和测试后，由左侧病变诱导引起的右后肢功能在6天内恢复。训练效果可能与重组和神经调节有关。运动恢复模式没有表明运动恢复是否依赖于病变周围的同侧皮层或对侧皮层。结论：结果强调，需要选择合适的程序，以提高运动功能的恢复，在这个模型中的皮质损伤的区域。
Primary Objective:To determine whether the ipsilateral cortex surrounding the lesion or the non-injured contralateral cortex is important for motor recovery after brain damage in the photochemically initiated thrombosis (PIT) model. Research Design:We induced PIT in the sensorimotor cortex in rats and examined the recovery of motor function using the beam-walking test.Methods and Procedures: In 24 rats, the right sensorimotor cortex was lesioned after 2 days of training for the beam-walking test (group 1). After 10 days, PIT was induced in the left sensorimotor cortex. Eight additional rats (group 2) received 2 days training in beam walking, then underwent the beam-walking test to evaluate function. After 10 days of testing, the left sensorimotor cortex was lesioned and recovery was monitored by the beam-walking test for 8 days. Main Outcomes and Results: In group 1 animals, left hindlimb function caused by a right sensorimotor cortex lesion recovered within 10 days after the operation. Right hindlimb function caused by the left-side lesion recovered within 6 days. In group 2, right hindlimb function caused by induction of the left-side lesion after a total of 12 days of beam-walking training and testing recovered within 6 days as with the double PIT model. The training effect may be relevant to reorganization and neuromodulation. Motor recovery patterns did not indicate whether motor recovery was dependent on the ipsilateral cortex surrounding the lesion or the cortex of the contralateral side. Conclusion: The results emphasize the need for selection of appropriate programs tailored to the area of cortical damage in order to enhance motor functional recovery in this model.