Do uterotonic drugs increase risk of abruptio placentae and eclampsia?
Do uterotonic drugs increase risk of abruptio placentae and eclampsia?
复制标题
子宫收缩药物会增加胎盘早剥和子痫的风险吗？
DOI：
10.1007/s00404-013-3101-8
复制
发表时间：
2014
影响因子：
2.6
通讯作者：
Minakami H.
中科院分区：
文献类型：
--
作者：
Morikawa M;Cho K;Yamada T;Yamada T;Sato S;Minakami H.
PurposeTo确定是否使用子宫收缩剂，包括催产素和异丙肾上腺素，增加胎盘早剥和子痫的风险。Materials and MethodsA回顾性分析在260，174名日本妇女中进行。人口统计学特征进行了研究，作为可能的候选人的危险因素的胎盘剥离和子痫使用多变量Logistic回归analysis.ResultsA共1,058（0.41%）和147（0.06%）的妇女发展胎盘剥离和子痫，分别。在接受子宫收缩剂治疗的61，857名妇女中，分别有177名（0.29%）和42名（0.07%）发生胎盘早剥和子痫。多变量回归分析表明，子宫收缩剂不会增加发生胎盘早剥或子痫的风险。初次产次[优势比（95%置信区间）1.41（1.24-1.60）]，年龄≥35岁[1.17（1.03-1.33）]和存在高血压[2.42（1.93-3.03）]是胎盘早剥的独立危险因素，而提前妊娠[0.67（0.63-0.71）]则降低胎盘早剥的危险性。初次产次[优势比（95%置信区间）4.06（2.49-6.63）]，年龄<20岁[2.44（1.07-5.58）]，存在高血压[28.7（20.5-40.1）]，[2018 - 01 - 18]（1.11-1.47）]是子痫的独立危险因素。结论子宫收缩剂的使用并不增加胎盘早剥和子痫的危险性。
PurposeTo determine whether the use of uterotonics, including oxytocin and prostaglandins, increases the risk of abruptio placentae and eclampsia.Materials and methodsA retrospective analysis was conducted among 260,174 Japanese women at term. Demographic characteristics were studied as possible candidates for risk factors of abruptio placentae and eclampsia using multivariate logistic regression analyses.ResultsA total of 1,058 (0.41 %) and 147 (0.06 %) women developed abruptio placentae and eclampsia, respectively. Abruptio placentae and eclampsia occurred in 177 (0.29 %) and 42 (0.07 %) of the 61,857 women treated with uterotonics, respectively. Multivariate regression analyses indicated that uterotonics did not increase risk of developing either abruptio placentae or eclampsia. Primiparity [odds ratio (95 % confidence interval) 1.41 (1.24–1.60)], age ≥35 years [1.17 (1.03–1.33)], and presence of hypertension [2.42 (1.93–3.03)] were significant independent risk factors for abruptio placentae, while advancing gestation [0.67 (0.63–0.71)] decreased risk of abruptio placentae. Primiparity [odds ratio (95 % confidence interval) 4.06 (2.49–6.63)], age <20 years [2.44 (1.07–5.58)], presence of hypertension [28.7 (20.5–40.1)], and advancing gestation [1.28 (1.11–1.47)] were significant independent risk factors for eclampsia.ConclusionThe use of uterotonics did not increase the risk of abruptio placentae and eclampsia.