Nonsteroidal antiinflammatory drugs and breast cancer risk - The multiethnic cohort
Nonsteroidal antiinflammatory drugs and breast cancer risk - The multiethnic cohort
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DOI：
10.1093/aje/kwm195
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发表时间：
2007-11-15
影响因子：
5
通讯作者：
Kolonel, Laurence N.
中科院分区：
文献类型：
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作者：
Gill, Jasmeet K.;Maskarinec, Gertraud;Kolonel, Laurence N.
以前关于非甾体类抗炎药（NSAID）和乳腺癌的研究产生了混合的结果。从1993年至2002年确定了多种族队列（非裔美国人、高加索人、日裔美国人、拉丁美洲人和来自夏威夷和加州的夏威夷土著人）中的乳腺癌侵袭性病例。关于阿司匹林、对乙酰氨基酚和其他NSAID（布洛芬、萘普生、吲哚美辛）使用的数据基于基线时（1993-1996年）的自填问卷。多变量考克斯比例风险模型提供了风险率比和95%置信区间的估计值。作者观察到，与非使用者相比，当前或过去使用阿司匹林的乳腺癌风险与使用阿司匹林的持续时间之间没有相关性（风险率比= 1.05，95%置信区间：0.88，1.25和风险率比= 1.04，95%置信区间：0.84，1.27对于>= 6年的使用）。然而，目前使用其他NSAID的持续时间具有保护作用。（危险率比= 0.70，95%置信区间：0.51，0.95，>= 6年使用; p（趋势）= 0.01），而过去使用没有（危险率比= 0.90，95%置信区间：0.62，1.30，>= 6年使用）。种族和激素受体状态的分析显示，目前使用的其他NSAID的保护作用仅限于高加索人和非裔美国人以及至少有一种阳性激素受体的女性。这项研究发现，目前使用其他NSAID的持续时间可以预防乳腺癌风险。
Previous studies on nonsteroidal antiinflammatory drugs (NSAIDs) and breast cancer have produced mixed results. Incident invasive cases of breast cancer from the Multiethnic Cohort (African Americans, Caucasians, Japanese Americans, Latinas, and Native Hawaiians from Hawaii and California) were identified from 1993 to 2002. Data on aspirin, acetaminophen, and other NSAID (ibuprofen, naproxen, indomethacin) use were based on a self-administered questionnaire at baseline (1993-1996). Multivariate Cox proportional hazards models provided estimates of hazard rate ratios and 95% confidence intervals. The authors observed no associations between breast cancer risk and duration of aspirin use for current or past users (hazard rate ratio = 1.05, 95% confidence interval: 0.88, 1.25 and hazard rate ratio = 1.04, 95% confidence interval: 0.84, 1.27 for >= 6 years of use, respectively) compared with nonusers. However, duration of current other NSAID use was protective (hazard rate ratio = 0.70, 95% confidence interval: 0.51, 0.95 for >= 6 years of use; p(trend) = 0.01) against the risk of breast cancer, while past use was not (hazard rate ratio = 0.90, 95% confidence interval: 0.62, 1.30 for >= 6 years of use). Analyses by ethnicity and hormone receptor status showed that the protective effect of current other NSAID use was limited to Caucasians and African Americans and to women with at least one positive hormone receptor. This study found duration of current other NSAID use to be protective against breast cancer risk.