Product selectivity control induced by using liquid-liquid parallel laminar flow in a microreactor
Product selectivity control induced by using liquid-liquid parallel laminar flow in a microreactor
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DOI：
10.1039/c1ob05174a
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发表时间：
2011-01-01
影响因子：
3.2
通讯作者：
Atobe, Mahito
中科院分区：
文献类型：
--
作者：
Amemiya, Fumihiro;Matsumoto, Hideyuki;Atobe, Mahito
基于液-液平行层流的产物选择性控制已经通过使用微反应器成功地证明。我们的电化学微反应器系统通过结合使用合适的流动模式和相应的阴极材料，通过底物的化学选择性阴极还原，实现醛与烯丙基氯的区域选择性交叉偶联反应。通过对苯甲醛扩散系数的估算和计算流体力学模拟，证实了微反应器中液-液平行层流的形成。通过电化学测量确定苯甲醛在Bu 4 NClO 4-HMPA介质中的扩散系数为1.32 x 10（-7）cm（2）s（-1），并且使用该值的流动模拟揭示了在特定通道长度上在微反应器通道中形成明确的苯甲醛浓度梯度。另外，通过流态实验证实了液-液平行层流的必要性。
Product selectivity control based on a liquid-liquid parallel laminar flow has been successfully demonstrated by using a microreactor. Our electrochemical microreactor system enables regioselective cross-coupling reaction of aldehyde with allylic chloride via chemoselective cathodic reduction of substrate by the combined use of suitable flow mode and corresponding cathode material. The formation of liquid-liquid parallel laminar flow in the microreactor was supported by the estimation of benzaldehyde diffusion coefficient and computational fluid dynamics simulation. The diffusion coefficient for benzaldehyde in Bu4NClO4-HMPA medium was determined to be 1.32 x 10(-7) cm(2) s(-1) by electrochemical measurements, and the flow simulation using this value revealed the formation of clear concentration gradient of benzaldehyde in the microreactor channel over a specific channel length. In addition, the necessity of the liquid-liquid parallel laminar flow was confirmed by flow mode experiments.