Fimbria-fornix vs selective hippocampal lesions in rats: Effects on locomotor activity and spatial learning and memory
Fimbria-fornix vs selective hippocampal lesions in rats: Effects on locomotor activity and spatial learning and memory
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DOI：
10.1006/nlme.1997.3807
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发表时间：
1998-01-01
影响因子：
2.7
通讯作者：
Jarrard, L
中科院分区：
文献类型：
--
作者：
Cassel, JC;Cassel, S;Jarrard, L
中断在海马伞和背穹窿通过的轴突的行为效果进行了比较，选择性去除的细胞，包括海马与鹅膏蕈氨酸的影响。从手术后4.5个月开始，损伤和对照大鼠（i）使用强调工作记忆（WM）或参考记忆（RM）的方案在Morris水迷宫和八臂径向迷宫中进行训练，（ii）在家中笼中测试运动活动。与假手术组相比，两个损伤组的大鼠在大多数学习/记忆任务中受损，但两个损伤组之间存在一些有趣的差异。当与海马伞穹窿病变的大鼠（FIFX大鼠）海马大鼠（HIPP大鼠）在学习游泳到一个可见的平台，表现出更大的损害比FIFX大鼠在径向迷宫任务时，测试程序需要利用RM和WM在一个更苛刻的WM任务。在自发活动测试中，FIFX和对照组大鼠无差异，但HIPP大鼠比其他两组大鼠更活跃。4.5个月恢复期后获得的结果模式支持以下一般结论。(1)虽然与移除海马相比，中断穹窿海马伞中的轴突对行为的影响有一些相似之处，但也有一些重要的差异。(2)根据现有的研究结果，解释FIFX和HIPP大鼠之间差异的可能解释是，4.5个月的生存时间允许FIFX病变大鼠组的一些恢复。(3)众所周知，Morris水迷宫和径向臂迷宫任务提供了有用的空间学习和记忆过程的措施，我们的研究结果表明，这两个空间学习任务提供的信息可能在重要方面有所不同。(C)北京：科学出版社.
The behavioral effects of interrupting the axons that pass in the fimbria and dorsal fornix were compared with the effects of selective removal of the cells that comprise the hippocampus with ibotenic acid. Starting 4.5 months after surgery, lesioned and control rats were (i) trained in both the Morris water maze and the eight-arm radial maze using protocols that placed an emphasis on either working memory (WM) or reference memory (RM) and (ii) tested for locomotor activity in the home cage. In comparison to sham-operated rats, the rats fi om both lesion groups were impaired in most learning/memory tasks, but there were some interesting differences between the two lesioned groups. When compared to rats with fimbria-fornix lesions (FIFX rats) hippocampal rats (HIPP rats) were slower in learning to swim to a visible platform and showed a greater impairment than FIFX rats in the radial-maze task when the testing procedure required the utilization of RM and WM in a more demanding WM task. In the test of locomotor activity, FIFX and control rats did not differ, but HIPP rats were more active than the rats in both other groups. The pattern of results obtained after a 4.5-month recovery period support the following general conclusions. (1) While there are some similarities in the effects on behavior of interrupting the axons in the fimbria-fornix compared to removing the hippocampus, there are some important differences. (2) From the findings that are available, a possible explanation to account for the difference between FIFX and HIPP rats is that the 4.5-month survival time permitted some recovery in the group of rats with FIFX lesions. (3) While it is well known that the Morris water maze and the radial-arm maze tasks provide useful measures of spatial learning and memory processes, our results suggest that the information provided by the two spatial learning tasks may differ in important respects. (C) 1998 Academic Press.