Interfacial interactions between natural RBC membranes and synthetic polymeric nanoparticles.
Interfacial interactions between natural RBC membranes and synthetic polymeric nanoparticles.
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DOI：
10.1039/c3nr06371b
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发表时间：
2014-03-07
期刊：
影响因子：
6.7
通讯作者：
Zhang L
中科院分区：
文献类型：
--
作者：
Luk BT;Hu CM;Fang RH;Dehaini D;Carpenter C;Gao W;Zhang L
最近开发的红细胞膜遮盖的纳米颗粒（RBC-NP）平台的独特结构特征和隐身特性引起了人们对天然细胞膜和聚合物纳米颗粒基底之间界面相互作用的好奇心。本文中，检查了RBC-纳米颗粒的几个界面方面，包括膜覆盖的完整性、涂覆时的膜侧性以及聚合物颗粒的表面电荷和表面曲率对膜遮盖过程的影响。研究表明，RBC膜以正面向外的方式完全覆盖带负电荷的聚合物纳米颗粒，并增强了颗粒的胶体稳定性。膜遮盖工艺适用于直径范围为65至340 nm的颗粒基材。此外，该研究表明，RBC膜上的表面聚糖和底物性质在驱动和引导膜/颗粒组装中起着重要作用。这些发现进一步了解细胞膜和纳米尺度基板之间的动力学，并提供有价值的信息，对未来的发展和表征的细胞膜隐形纳米器件。
The unique structural features and stealth properties of a recently developed red blood cell membrane-cloaked nanoparticle (RBC-NP) platform raise curiosity over the interfacial interactions between natural cellular membranes and polymeric nanoparticle substrates. Herein, several interfacial aspects of the RBC-NPs are examined, including completeness of membrane coverage, membrane sidedness upon coating, and the effects of polymeric particles’ surface charge and surface curvature on the membrane cloaking process. The study shows that RBC membranes completely cover negatively charged polymeric nanoparticles in a right-side-out manner and enhance the particles’ colloidal stability. The membrane cloaking process is applicable to particle substrates with a diameter ranging from 65 to 340 nm. Additionally, the study reveals that both surface glycans on RBC membranes and the substrate properties play a significant role in driving and directing the membrane/particle assembly. These findings further the understanding of the dynamics between cellular membranes and nanoscale substrates and provide valuable information toward future development and characterization of cellular membrane-cloaked nanodevices.