Fibrinogen, other putative markers of inflammation, and weight gain in middle-aged adults - The ARIC study
Fibrinogen, other putative markers of inflammation, and weight gain in middle-aged adults - The ARIC study
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DOI：
10.1038/oby.2000.33
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发表时间：
2000-07-01
期刊：
影响因子：
--
通讯作者：
Heiss, G
中科院分区：
文献类型：
--
作者：
Duncan, BB;Schmidt, MI;Heiss, G
目的：体重增加是代谢综合征发生的重要危险因素，炎症介质与代谢综合征密切相关。我们的目的是调查炎症是否能预测人群体重增加的发展。研究方法和程序：我们在一个由13017名45 - 64岁的男性和女性组成的双种族队列中，使用多元线性和逻辑回归模型，研究了在大约3年的时间里预测体重增加的炎症标志物。结果：在调整后的模型中，纤维蛋白原最高四分位数的小鼠获得了？在前3年随访期间，估计比最低四分位数的患者多0.23 kg/年（p < 0.001）。纤维蛋白原含量最高的四分位数患者体重大幅增加（大于第90百分位数）的调整后几率是最低四分位数患者体重增加的1.65倍（95%可信区间[CI]， 1.38至1.97）。同样，对于那些白细胞计数、VIII因子和血管性血友病因子水平高的人来说，体重大幅增加的优势比分别为1.38（1.14至1.67）、1.28（1.08至1.53）和1.28（1.08至1.51）。讨论：纤维蛋白原和其他假定的炎症标志物预测中年人体重增加。鉴于炎症反应和中间代谢之间的已知联系以及社区动脉粥样硬化风险队列（ARIC）的方法学优势，这些发现虽然没有立即的临床适用性，但表明炎症过程在代谢综合征和心血管疾病的发展中部分通过刺激体重增加发挥作用。
Purpose: Weight gain is an important risk factor for theevelopment of the metabolic syndrome, and inflammatory mediators are strongly associated with this syndrome. Our aim was to investigate whether inflammation predicts the development of weight gain in populations.Research Methods and Procedures: We investigated selected markers of inflammation in the prediction of weight gain over an approximately 3-year period in a biethnic cohort of 13,017 men and women, 45 to 64 years of age, using multiple linear and logistic regression modeling.Results: In adjusted models, those in the highest quartile of fibrinogen gained? during the first 3 years of follow-up, an estimated 0.23 kg/year more than those in the lowest quartile (p < 0.001). Adjusted odds of a large (greater than the 90th percentile) weight gain for those in the highest quartile of fibrinogen were 1.65 (95% confidence interval [CI], 1.38 to 1.97) times those in the lowest quartile. Similarly adjusted odds ratios for a large weight gain for those with high levels of white blood cell count, factor VIII, and von Willebrand factor were 1.38 (1.14 to 1.67), 1.28 (1.08 to 1.53), and 1.28 (1.08 to 1.51), respectively.Discussion: Fibrinogen and other putative markers of inflammation predict weight gain in middle-aged adults. Given the known links between the inflammatory response and intermediary metabolism and the methodological strengths of the Atherosclerosis Risk in Communities (ARIC) cohort, these findings, though without immediate clinical applicability, suggest that inflammatory processes play a role in the development of the metabolic syndrome and cardiovascular disease in part through stimulation of weight gain.