Modulation of inferotemporal cortex activation during verbal working memory maintenance
Modulation of inferotemporal cortex activation during verbal working memory maintenance
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DOI：
10.1016/j.neuron.2006.06.007
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发表时间：
2006-07-20
期刊：
影响因子：
16.2
通讯作者：
D'Esposito, Mark
中科院分区：
文献类型：
--
作者：
Fiebach, Christian J.;Rissman, Jesse;D'Esposito, Mark
左侧颞下皮层的区域与视觉词识别和语义有关。我们利用功能性磁共振成像来定位颞下语言区域，并证明该区域参与工作记忆中视觉呈现单词的主动维护。这个颞下区域的维持活动显示了单词记忆负荷的影响，但对假词没有影响。在没有视觉输入的情况下，这种与语言相关的颞下区域的选择性调节与左前额叶皮层的功能连接增加有关。这些结果证明了颞下皮层参与了言语工作记忆，并为非语音语言表征可以被用于言语工作记忆的概念提供了神经生理学支持。更一般地说，他们认为言语工作记忆应该被概念化为预先存在的皮层语言表征的前额引导、持续激活。
Regions of the left inferotemporal cortex are involved in visual word recognition and semantics. We utilized functional magnetic resonance imaging to localize an inferotemporal language area and to demonstrate that this area is involved in the active maintenance of visually presented words in working memory. Maintenance activity in this inferotemporal area showed an effect of memory load for words, but not pseudowords. In the absence of visual input, the selective modulation of this language-related inferotemporal area for the maintenance of words is accompanied by an increased functional connectivity with left prefrontal cortex. These results demonstrate an involvement of inferotemporal cortex in verbal working memory and provide neurophysiological support for the notion that nonphonological language representations can be recruited in the service of verbal working memory. More generally, they suggest that verbal working memory should be conceptualized as the frontally guided, sustained activation of pre-existing cortical language representations.