Genetic characterization of novel reassortant H5N6-subtype influenza viruses isolated from cats in eastern China
Genetic characterization of novel reassortant H5N6-subtype influenza viruses isolated from cats in eastern China
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DOI：
10.1007/s00705-017-3490-2
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发表时间：
2017-11-01
影响因子：
2.7
通讯作者：
Xu, Lihua
中科院分区：
文献类型：
--
作者：
Cao, Xueliang;Yang, Fan;Xu, Lihua
猫易感染甲型流感病毒，因此可能成为家庭内的传播媒介，构成潜在的公共卫生问题。2016年在中国东部浙江省从猫中分离出两种新型重组H5N6流感病毒。两种病毒均采用全基因组测序，随后进行系统发育分析和遗传比较。系统发育分析表明，这些病毒的基因来源于中国分离的H5N6、H9N2和H7N9流感病毒。这些H5N6病毒能够在没有事先适应的情况下在小鼠中复制。我们的研究结果表明，这些病毒的持续传播可能危及人类。
Cats are susceptible to influenza A viruses and therefore may act as transmission vectors within households, posing a potential public health concern. Two novel reassortant H5N6 influenza viruses were isolated from cats in Zhejiang Province, Eastern China, in 2016. Both viruses were characterized by whole-genome sequencing with subsequent phylogenetic analysis and genetic comparison. Phylogenetic analysis showed that these viruses received their genes from H5N6, H9N2, and H7N9 influenza viruses isolated from China. These H5N6 viruses were able to replicate in mice without prior adaptation. Our results show that continued circulation of these viruses could endanger humans.