Irradiation-mediated carbon nanotubes' use in cancer therapy.
Irradiation-mediated carbon nanotubes' use in cancer therapy.
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DOI：
10.4103/0973-1482.103511
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发表时间：
2012-07
影响因子：
1.3
通讯作者：
Jingang Yu;F. Jiao;Xiao-qing Chen;Xin-yu Jiang;Zhiguang Peng;Dong-ming Zeng;Du-shu Huang
中科院分区：
文献类型：
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作者：
Jingang Yu;F. Jiao;Xiao-qing Chen;Xin-yu Jiang;Zhiguang Peng;Dong-ming Zeng;Du-shu Huang
抗癌药物如生物治疗性蛋白质和肽用于治疗各种肿瘤。然而，它们的生物利用度差和体内作用位点不可控阻碍了它们的广泛应用。肿瘤纳米治疗技术发展迅速，正在解决传统给药系统的一些局限性。为了改善抗癌药物的生物分布，碳纳米管已被用作最有效的药物载体之一。本文综述了碳纳米管介导的抗癌药物释放方法，重点介绍了辐射诱导的靶向释放和选择性光热治疗肿瘤。
Anticancer drugs such as biological therapeutic proteins and peptides are used for treatment of a variety of tumors. However, their wider use has been hindered by their poor bioavailability and the uncontrollable sites of action in vivo. Cancer nano-therapeutics is rapidly progressing, which is being applied for solving some limitations of conventional drug delivery systems. To improve the bio-distribution of anticancer drugs, carbon nanotubes have been used as one of the most effective drug carriers. This review discusses the carbon nanotubes-mediated methods for the delivery of anticancer drugs, with emphasis on the radiation-induced drug-targeted releasing and selective photo-thermal cancer therapy.