Neuroleptic Malignant Syndrome or Lithium Neurotoxicity
Neuroleptic Malignant Syndrome or Lithium Neurotoxicity
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抗精神病药恶性综合征或锂神经毒性
DOI：
10.1192/bjp.150.4.568b
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发表时间：
1987
影响因子：
10.5
通讯作者：
A. Jee
中科院分区：
文献类型：
--
作者：
A. Jee
精神损害、精神病、酗酒或头部损伤病史(Harvey，1986)。他们接受了额叶功能测试和韦施勒成人智力量表(WAIS)的分项测试。使用Nelson‘s改良威斯康星卡片分类测验(MWCST)的匹配常模数据，强迫症患者的持久度显著高于常模(t=2.80，P=0.01)。他们的平均持之以恒百分比(50%，S.D.=31)大于额叶肉眼损伤患者(42%，S.D.在WAIS的年龄分项测试中，没有或没有明显影响的观察者具有可比性。坚持性与Leyton强迫症状量表的强迫程度呈正相关(Spearman‘s r=0.5，P=0.01)，与交替类别语言流利性呈负相关(r=0.62，P=0.002)。后一项测试和MWCST评估认知集转移能力，这是一种特定的额叶功能。尽管强迫症可能会影响认知任务，如ACVF测试，但在此基础上，似乎不太可能发生坚持不懈等定性上的明显错误。整体业绩受损的可能性似乎更大，尽管从WAIS的分项测试中看不出这一点。因此，特发性强迫症是否与额叶损伤相关，需要作为一个具体问题来看待。不应假设这种损伤必然意味着已知的脑损伤的存在。
impairment, psychosis, alcoholism, or a history of head injury (Harvey, 1986). They were given tests of frontal lobe functions and sub-tests of the Weschler Adult Intelligence Scale (WAIS). Using matched normative data for Nelson's Modified Wisconsin Card Sorting Test (MWCST), the obsessionals were shown to perseverate significantly more than normals (t= 2.80, P=0.01). Their mean percentage perseveration (50%, s.d. = 31) was greater than for patients with gross frontal lobe damage (42%, s.d. = 25).Obsessionals withor withoutsignificant persev eration were comparable on age-scaled sub-tests of the WAIS. Perseveration correlated with degree of obsessionality on the Leyton Obsessional Inventory (Spearman's r=0.50, P=0.Ol), which also corre lated, negatively, with alternating category verbal fluency (ACVF) (r= —¿ 0.62, P=0.002). This latter test and the MWCST assess cognitive set-shifting ability, a specific frontal lobe function. AlthoughOCDcouldaffectcognitive tasks, such as theACVFtest, via impaired performanceefficiency, it seems unlikely that a qualitatively distinctive error, such as perseveration, would occur on this basis. An overall impairment of performance would seem more likely, although this was not evident from the WAIS sub-tests. Whether or not idiopathic OCD is associated with frontal impairment therefore needs to be looked at as a specific issue. It should not be assumed that such impairment necessarily implies the presence of a known brain injury.