Environmental-temperature and internal-state dependent thermotaxis plasticity of nematodes
Environmental-temperature and internal-state dependent thermotaxis plasticity of nematodes
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DOI：
10.1016/j.conb.2022.102541
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发表时间：
2022-04
影响因子：
5.7
通讯作者：
A. Takeishi
中科院分区：
文献类型：
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作者：
A. Takeishi
秀丽隐杆线虫的趋热行为健壮且可塑性强。一对感觉神经元AFD记忆环境/培养温度，并与下游神经回路通信以调节动物的温度偏好。这导致行为偏差，其中蠕虫将在热梯度上朝向其培养温度移动。秀丽隐杆线虫的趋热性也受体内状态的影响，当蠕虫饥饿时，趋热性暂时消失。在这里，我将讨论如何C. elegansis能够调整其行为的基础上，温度通过整合环境和内部信息。最近的研究表明，一些寄生线虫具有与秀丽隐杆线虫相似的温度感受机制，并表现出培养温度依赖性趋热性。本文还将讨论秀丽隐杆线虫和粪类圆线虫的温度感觉和趋热性调节的共同神经机制。
Thermotaxis behavior ofCaenorhabditis elegansis robust and highly plastic. A pair of sensory neurons, AFD, memorize environmental/cultivation temperature and communicate with a downstream neural circuit to adjust the temperature preference of the animal. This results in a behavioral bias where worms will move toward their cultivation temperature on a thermal gradient. Thermotaxis ofC. elegansis also affected by the internal state and is temporarily abolished when worms are starved. Here I will discuss howC. elegansis able to modulate its behavior based on temperature by integrating environmental and internal information. Recent studies show that some parasitic nematodes have a similar thermosensory mechanism toC. elegansand exhibit cultivation-temperature-dependent thermotaxis. I will also discuss the common neural mechanisms that regulate thermosensation and thermotaxis inC. elegansandStrongyloides stercoralis.