Genetic risk factors and ischaemic cerebrovascular disease:: role of common variation of the genes encoding apolipoproteins and angiotensin-converting enzyme
Genetic risk factors and ischaemic cerebrovascular disease:: role of common variation of the genes encoding apolipoproteins and angiotensin-converting enzyme
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DOI：
10.3109/07853899808999408
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发表时间：
1998-04-01
影响因子：
4.4
通讯作者：
Kontula, K
中科院分区：
文献类型：
--
作者：
Aalto-Setälä, K;Palomäki, H;Kontula, K
编码载脂蛋白 (apo) A-I、C-m、B 和 E 以及血管紧张素转换酶 (ACE) 的基因 DNA 多态性已被认为与冠状动脉疾病 (CAD) 的风险相关。我们研究了相同的遗传标记是否也与颈动脉粥样硬化的发生和程度相关。对 234 名中风或短暂性脑缺血发作幸存者的 DNA 样本进行了检查，这些幸存者的年龄为 GO 梨或以下。使用主动脉弓血管造影评估动脉粥样硬化的存在。分析apoA-I/C-III基因位点SstI多态性、apoB基因XbaI多态性、常见apoE表型以及ACE基因插入/缺失多态性。 apoA-I/C-III、apoB、apoE 或 ACE 基因的等位基因频率在有（It = 148）或无（n = 85）颈动脉粥样硬化组之间没有差异。然而，当将至少具有一个 apoE4 等位基因和一个 apoB 的一个 X2 等位基因的患者组合起来，并与没有其中任何一个的患者（E2E3 或 E3E3 和 X1X1）进行比较时，发现与颈动脉粥样硬化存在显着相关性（P = 0.03）。与E3E3表型患者相比，E2E3表型患者血清甘油三酯水平显着升高（P = 0.03）。 E2E3表型患者的血清高密度脂蛋白（HDL）胆固醇低于E3E3和E3E4表型患者（分别为P = 0.01和P = 0.06）。 apoB 或 ACE 基因型与血清脂质或脂蛋白水平没有显着相关。 ACE基因多态性与高血压的发生无相关性。总之，常见的apoB和apoE等位基因的相互作用可能会增加颈动脉粥样硬化的风险。
DNA polymorphisms in genes encoding apolipoproteins (apo) A-I, C-m, B and E and angiotensin-converting enzyme (ACE) have been proposed to be associated with the risk of coronary artery disease (CAD). We studied whether the same genetic markers would also be associated with the occurrence and extent of atherosclerosis in cervical arteries. DNA samples from 234 survivors of stroke or a transient ischaemic attack aged GO pears or less were examined. The presence of atherosclerosis was assessed using aortic arch angiograms. The SstI polymorphism of apoA-I/C-III gene locus, the XbaI polymorphism of apoB gene, common apoE phenotypes and the insertion/deletion polymorphism of the ACE gene were analysed. The allele frequencies of the apoA-I/C-III, apoB, apoE or ACE gene did not differ between the groups with (It = 148) or without (n = 85) cervical atherosclerosis. However, when patients with at least one apoE4 allele and one X2 allele of apoB were combined and compared with those without either of them (E2E3 or E3E3 and X1X1), a significant association with the presence of cervical atherosclerosis was found (P = 0.03). The patients having the E2E3 phenotype had a significantly elevated serum triglyceride level compared with those with the E3E3 phenotype (P = 0.03). Serum high-density lipoprotein (HDL) cholesterol was lower in the patients with the E2E3 phenotype than in those with the E3E3 and E3E4 (P = 0.01 and P = 0.06, respectively). The apoB or ACE genotypes were not significantly associated with serum lipid or lipoprotein levels. There was no association between the ACE gene polymorphism and the occurrence of hypertension. In conclusion, the interaction of common apoB and apoE alleles may increase the risk of atherosclerosis in cervical arteries.