DISTRIBUTION OF THE MAMMALIAN STAT GENE FAMILY IN MOUSE CHROMOSOMES
DISTRIBUTION OF THE MAMMALIAN STAT GENE FAMILY IN MOUSE CHROMOSOMES
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DOI：
10.1006/geno.1995.1235
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发表时间：
1995-09-01
期刊：
影响因子：
4.4
通讯作者：
JENKINS, NA
中科院分区：
文献类型：
--
作者：
COPELAND, NG;GILBERT, DJ;JENKINS, NA
通过干扰素和多种细胞因子的转录激活的研究已经导致鉴定作为信号转导子和转录激活子的蛋白质家族，Stats。在这里，我们报告了七个小鼠Stat基因座在三个簇中的映射，每个簇位于不同的小鼠常染色体上。这些数据表明，该家族是通过祖先基因座的串联重复，然后将连锁基因座分散到不同的小鼠染色体上而产生的。(C)出版社：Academic Press
Studies of transcriptional activation by interferons and a variety of cytokines have led to the identification of a family of proteins that serve as signal transducers and activators of transcription, Stats. Here, we report that the seven mouse Stat loci map in three clusters, with each cluster located on a different mouse autosome. The data suggest that the family has arisen via a tandem duplication of the ancestral locus, followed by dispersion of the linked loci to different mouse chromosomes. (C) 1995 Academic Press, Inc.