Inherited predisposition to preeclampsia: Analysis of the Aberdeen intergenerational cohort
Inherited predisposition to preeclampsia: Analysis of the Aberdeen intergenerational cohort
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DOI：
10.1016/j.preghy.2017.03.001
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发表时间：
2017-04-01
影响因子：
2.2
通讯作者：
Bhattacharya, Sohinee
中科院分区：
文献类型：
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作者：
Ayorinde, Abimbola A.;Bhattacharya, Sohinee
目的：在考虑其他危险因素的同时，评估先兆子痫和妊娠合并妊娠高血压综合征的家庭危险程度。方法：从阿伯丁孕产妇和新生儿数据库(AMND)提取代际数据集，该数据库记录了苏格兰阿伯丁自1950年以来所有的妊娠和分娩细节。这项分析包括所有未分娩的妇女，她们的母亲在出生时的记录也被记录在AMND中。结果：17302例未产妇中，子痫前期1057例(6.1%)，妊娠期高血压4098例(23.7%)。424例(2.5%)有先兆子痫史，2940例(17.0%)有妊娠期高血压病史。妊娠期合并子痫前期的孕妇发生子痫前期的风险较高(调整后RRR为2.55，95%CI为1.87~3.47)。这高于母亲患有妊娠期高血压的妇女的风险(调整后的RRR为1.44，95%CI为1.23-1.69)。妊娠期高血压的风险与母亲妊娠高血压的风险相似(调整后RRR为1.37 95%CI 1.09~1.71)。结论：子痫前期的遗传方式存在剂量反应效应，且以先兆子痫的风险最高。妊娠期高血压表现出与母亲妊娠期高血压和先兆子痫相似的风险增加。(C)2017国际妊娠期高血压研究学会。爱思唯尔出版，版权所有。
Objective: To assess the magnitude of familial risk of preeclampsia and gestational hypertension in women born of a preeclamptic pregnancy and those born of pregnancy complicated by gestational hypertension while accounting for other risk factors.Methods: An intergenerational dataset was extracted from the Aberdeen Maternity and Neonatal Databank (AMND) which records all pregnancy and delivery details occurring in Aberdeen, Scotland since 1950. The analysis included all nulliparous women whose mothers' records at their births are also recorded in the AMND. Multinomial logistic regression was used to assess the risk of having preeclampsia or gestational hypertension based on maternal history of preeclampsia or gestational hypertension.Results: There were 17302 nulliparous women included, of whom 1057(6.1%) had preeclampsia while 4098(23.7%) had gestational hypertension. Furthermore, 424(2.5%) and 2940(17.0%) had maternal history of preeclampsia and gestational hypertension respectively. The risk of preeclampsia was higher in women who were born of pregnancies complicated by preeclampsia (adjusted RRR 2.55 95% CI 1.87-3.47). This was higher than the risk observed in women whose mothers had gestational hypertension (adjusted RRR 1.44 95% CI 1.23-1.69). Conversely, the risk of gestational hypertension was similar in those who were born of preeclamptic pregnancies (adjusted RRR 1.37 95% CI 1.09-1.71) and those whose mothers had gestational hypertension (adjusted RRR 1.36 95% CI 1.24-1.49).Conclusion: There was a dose response effect in the inheritance pattern of preeclampsia with the highest risk in women born of preeclamptic pregnancies. Gestational hypertension showed similar increased risk with maternal gestational hypertension and preeclampsia. (C) 2017 International Society for the Study of Hypertension in Pregnancy. Published by Elsevier B.V. All rights reserved.