Recent advances in radiotherapy.

Recent advances in radiotherapy.
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DOI:
10.1186/1741-7015-8-25
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发表时间:
2010-04-28
期刊:
影响因子:
9.3
通讯作者:
Nutting CM
Nutting CM
中科院分区:
医学1区
文献类型:
--
作者:
Bhide SA;Nutting CM

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放射治疗已经从基于肿瘤周围大边缘的正交X光照片的治疗计划走了很长一段路。成像和放射计划软件的进步导致了三维适形放射治疗,并进一步导致了调强放射治疗(IMRT)。调强放射治疗允许保留正常组织,从而使肿瘤的剂量递增。调强放射治疗是目前治疗头部和前列腺癌的标准,目前正在对其他肿瘤部位进行研究。调强放射治疗中精细的剂量分布(增加了地理遗漏),再加上放射治疗过程中肿瘤的运动和解剖变化,使得图像引导放射治疗成为现代放射治疗的重要组成部分。目前正在研究各种硬件和软件工具,以实现最佳的IGRT。
Radiation therapy has come a long way from treatment planning based on orthogonal radiographs with large margins around tumours. Advances in imaging and radiation planning software have led to three-dimensional conformal radiotherapy and, further, to intensity modulated radiotherapy (IMRT). IMRT permits sparing of normal tissues and hence dose-escalation to tumours. IMRT is the current standard in treatment of head and prostate cancer and is being investigated in other tumour sites. Exquisitely sculpted dose distributions (increased geographical miss) with IMRT, plus tumour motion and anatomical changes during radiotherapy make image guided radiotherapy an essential part of modern radiation delivery. Various hardware and software tools are under investigation for optimal IGRT.
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