Preserving Cognition in Older African Americans with Mild Cognitive Impairment.
Preserving Cognition in Older African Americans with Mild Cognitive Impairment.
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保持患有轻度认知障碍的老年非裔美国人的认知能力。
DOI：
10.1111/jgs.14012
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发表时间：
2016
影响因子：
6.3
通讯作者：
Casten,RobinJ
中科院分区：
文献类型：
--
作者：
Rovner,BarryW;Casten,RobinJ
方法在基线和12个月（不考虑治疗分配）时，我们使用霍普金斯语言学习测试-修订延迟回忆（HVLT）和统一数据集（UDS）神经心理学测试，包括评估言语记忆、注意力、语义记忆、语言、处理速度、视觉空间能力和执行功能的测试。从UDS的各个测试中得到标准化的分数，即UDS- cs (UDS- composite Score)，它反映了全局认知。我们的试点数据表明，在临床上，每减少0.45个UDS-CS点，就意味着无法平衡支票簿、洗衣服、购物或做饭。结果参与者平均年龄75.1岁（SD 6.8）；28例（80%）为女性。从表中可以看出，在12个月的时间里，接受行为激活的参与者在情景记忆（HVLT）和执行功能/处理速度[数字符号替代测试（DSST）]两个认知领域的得分都有所提高。支持性治疗对照组没有类似的改善。在UDS-CS中，与支持治疗相比，接受行为激活的参与者比例提高了≥0.45分[40.0%对21.1%；或者：2.50美元。[55-11.33]，较少者下降≥0.45点[6.7% vs. 21.1%；或：0.27(。03 - 2.70)]。其他神经心理测试分数没有明显变化。
MethodsAt baseline and 12 months (masked to treatment assignment), we administered the Hopkins Verbal Learning Test-Revised Delayed Recall (HVLT) and the Uniform Data Set (UDS) Neuropsychological Battery, which includes tests assessing verbal memory, attention, semantic memory, language, processing speed, visuospatial ability, and executive function. Standardized z scores from the component UDS tests yield the UDS-Composite Score (UDS-CS), which reflects global cognition. Our pilot data indicate that a decrement of 0.45 UDS-CS points translates clinically to the inability to balance a checkbook, do laundry, shop, or prepare meals.ResultsThe average age of participants was 75.1 years (SD 6.8); 28 (80%) were women. The Table shows that participants who received Behavioral Activation had improved scores over 12 months in 2 cognitive domains: episodic memory (HVLT score) and executive function/processing speed [Digit Symbol Substitution Test (DSST)]. Supportive Therapy controls had no comparable improvements. On the UDS-CS, a greater proportion of participants who received Behavioral Activation compared to Supportive Therapy improved by≥ 0.45 points [40.0% vs. 21.1%; OR: 2.50 (. 55–11.33)], and fewer declined by≥ 0.45 points [6.7% vs. 21.1%; OR: 0.27 (. 03–2.70)]. There were no significant changes in other neuropsychological test scores.