Acute and subacute toxicities of the saponin mixture isolated from Schefflera leucantha Viguier.
Acute and subacute toxicities of the saponin mixture isolated from Schefflera leucantha Viguier.
复制标题
从白花鹅掌柴中分离出的皂苷混合物的急性和亚急性毒性。
DOI：
10.1016/s0378-8741(03)00273-3
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发表时间：
2003
影响因子：
5.4
通讯作者：
N. Lertprasertsuke
中科院分区：
文献类型：
--
作者：
P. Witthawaskul;A. Panthong;D. Kanjanapothi;T. Taesothikul;N. Lertprasertsuke
通过与该植物的甲醇和水提取物进行比较，研究了从白鹅掌叶中分离出的支气管扩张剂皂苷混合物的急性毒性。口服剂量5000mg/kg的甲醇提取物、水提取物和皂苷混合物不会导致大鼠死亡或一般行为和内脏器官的总体外观发生显着变化。以1000mg/kg剂量，口服14天评价皂苷合剂的亚急性毒性。另外一组（卫星组）给予皂苷混合物，并在治疗后继续保持 14 天。所有动物在实验期间均未表现出中毒迹象。与接受蒸馏水的对照组相比，皂苷处理组和卫星雄性组的肝脏重量较高，而睾丸重量较低。然而，各器官的组织学检查显示，对照组和治疗组大鼠之间没有差异。接受皂苷的大鼠中，BUN、Cr、AST、ALT 和 ALP 水平升高。皂苷混合物可能直接影响肝脏和肾脏功能。
Acute toxicity of the bronchodilator saponin mixture isolated from Schefflera leucantha Viguier leaves was investigated in comparison with the methanol and the water extract of this plant. Oral doses of 5000mg/kg of the methanol extract, the water extract and the saponin mixture did not produce mortality or significant changes in the general behavior and gross appearance of internal organs of rats. Subacute toxicity of the saponin mixture was evaluated with the dose of 1000mg/kg, orally for 14 days. An extra group (satellite group) was given saponin mixture and kept for a further 14 days after treatment. All animals did not show signs of toxicity during the experimental period. Liver weights of the saponin-treated and the satellite male groups were higher whereas testis weight were lower than those of the control group which received distilled water. However, the histological examination of various organs revealed that there were no differences between the control and the treated rats. BUN, Cr, AST, ALT and ALP levels increased in saponin-receiving rats. It is possible that the saponin mixture directly impacts on the liver and the kidney functions.