Differential uptake of salicylate in serum, cerebrospinal fluid, and perilymph.
Differential uptake of salicylate in serum, cerebrospinal fluid, and perilymph.
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DOI：
10.1001/archotol.1986.03780100038004
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发表时间：
1986-10
期刊：
影响因子：
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通讯作者：
P. Jastreboff;R. Hansen;P. G. Sasaki;C. Sasaki
中科院分区：
文献类型：
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作者：
P. Jastreboff;R. Hansen;P. G. Sasaki;C. Sasaki
在麻醉大鼠和豚鼠腹腔注射水杨酸盐后，我们发现外淋巴液(PL)中的水杨酸水平与脑脊液(CSF)中的药物浓度和血清中的药物浓度都密切相关，且系统地观察到外淋巴液中的水杨酸浓度高于脑脊液中的浓度。进一步的分析表明，水杨酸盐不是被动地通过脑脊液进入PL，而是直接从血液输送到PL。大鼠摄取水杨酸的时间进程在1 1/2小时(血清)和2~4小时(脑脊液和PL)达到最高水平。另一方面，水杨酸在豚鼠血清和脑脊液中的摄取呈现较长的时间过程，在血清和脑脊液中分别在4小时和5小时达到最高水平。这些以前没有的数据，是我们理解水杨酸盐相关听觉效应的基础。
After intraperitoneal administration of salicylate in anesthetized rats and guinea pigs, we found that salicylate levels in perilymph (PL) are closely related to both drug levels in cerebrospinal fluid (CSF) and in serum, with higher levels systematically observed in PL than in CSF. Further analysis suggests that salicylate is not passively transported into PL across CSF but, rather, is transported from blood directly to PL. The time course of salicylate uptake in rats reveals maximum levels at 1 1/2 hours (serum) and two to four hours (CSF and PL). On the other hand, salicylate uptake into serum and CSF of guinea pigs exhibits a longer time course, with maximum levels reached at four hours (serum) and five hours (CSF). These data, not previously available, are basic to our understanding of salicylate-related auditory effects.