Embryonic stem cells in cardiac repair and regeneration.

Embryonic stem cells in cardiac repair and regeneration.
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DOI:
10.1089/ars.2009.2491
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发表时间:
2009-08
影响因子:
6.6
通讯作者:
Singla DK
Singla DK
中科院分区:
生物学2区
文献类型:
--
作者:
Singla DK

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细胞移植是一项快速发展的研究,具有治疗心脏病的潜力。临床应用需要制备大量的供体细胞。迄今为止发表的干细胞研究表明,科学家尚未就使用最佳细胞类型实现更好的心脏修复和再生达成普遍共识。我们使用胚胎干 (ES) 细胞及其释放的因子进行心脏修复和再生。使用干细胞进行心脏再生的主要问题包括 ES 细胞移植后的植入、分化和畸胎瘤形成。我们目前对心脏 ES 细胞移植的了解非常有限。本综述将讨论使用各种生长因子来增强 ES 细胞的植入和分化以及畸胎瘤形成的问题。
Cell transplantation is a fast growing research with a potential of therapeutic approach for the treatment of heart diseases. Clinical applications require preparation of large number of donor cells. Stem cell studies published todate demonstrate that scientist have not reached at the general consensus to use optimal cell type for better cardiac repair and regeneration. We use embryonic stem (ES) cells and their released factors for cardiac repair and regeneration. The major concern of cardiac regeneration using stem cells includes engraftment, differentiation and teratoma formation following ES cell transplantation. Our current knowledge of ES cell transplantation in the heart is very limited. This review will discuss the use of various growth factors to enhance ES cells engraftment and differentiation as well as the issue of teratoma formation.
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