Sox2+ stem cells contribute to all epithelial lineages of the tooth via Sfrp5+ progenitors.
Sox2+ stem cells contribute to all epithelial lineages of the tooth via Sfrp5+ progenitors.
复制标题
DOI：
10.1016/j.devcel.2012.05.012
复制
发表时间：
2012-08-14
影响因子：
11.8
通讯作者：
Michon, Frederic
中科院分区：
文献类型：
--
作者：
Juuri, Emma;Saito, Kan;Ahtiainen, Laura;Seidel, Kerstin;Tummers, Mark;Hochedlinger, Konrad;Klein, Ophir D.;Thesleff, Irma;Michon, Frederic
不断生长的小鼠门牙是研究器官更新过程中干细胞调节的有价值的模型。上皮干细胞位于唇颈环中切牙的近端。在这里，我们证明转录因子 Sox2 是这些干细胞的特异性标记。在牙齿形态发生过程中，Sox2+细胞被限制在唇颈环中，它们有助于产生牙釉质的成釉细胞以及牙齿所有其他上皮细胞谱系的更新。 Sox2阳性干细胞的早期后代短暂表达Wnt抑制剂Sfrp5。 Sox2 的表达受到牙齿起始标记 FGF8 和特定 miRNA 的调节，表明通过微调来维持牙上皮的稳态。 Sox2作为牙上皮干细胞标记物的鉴定将有助于进一步研究其在牙齿更新过程中的谱系分离和分化。
The continuously growing mouse incisor serves as a valuable model to study stem cell regulation during organ renewal. Epithelial stem cells are localized in the proximal end of the incisor in the labial cervical loop. Here, we show that the transcription factor Sox2 is a specific marker for these stem cells. Sox2+ cells became restricted to the labial cervical loop during tooth morphogenesis, and they contributed to the renewal of enamel-producing ameloblasts as well as all other epithelial cell lineages of the tooth. The early progeny of Sox2-positive stem cells transiently expressed the Wnt inhibitor Sfrp5. Sox2 expression was regulated by the tooth initiation marker FGF8 and specific miRNAs, suggesting a fine-tuning to maintain homeostasis of the dental epithelium. The identification of Sox2 as a marker for the dental epithelial stem cells will facilitate further studies on their lineage segregation and differentiation during tooth renewal.
登录
查看更多内容
DOI：
10.1083/jcb.200409182
发表时间：
2005-03-28
期刊：
The Journal of cell biology
影响因子：
--
作者：
Mansukhani A;Ambrosetti D;Holmes G;Cornivelli L;Basilico C
通讯作者：
Basilico C
DOI：
10.1126/science.1180794
发表时间：
2010-01-29
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Li L;Clevers H
通讯作者：
Clevers H
影响因子：
5.3
作者：
Lustig, B;Jerchow, B;Behrens, J
通讯作者：
Behrens, J
影响因子：
2.7
作者：
Michon, Frederic;Tummers, Mark;Thesleff, Irma
通讯作者：
Thesleff, Irma
影响因子：
64.5
作者：
Kim, Jonghwan;Chu, Jianlin;Orkin, Stuart H.
通讯作者：
Orkin, Stuart H.