Cytotoxic Acylphloroglucinol Derivatives from Callistemon salignus.
Cytotoxic Acylphloroglucinol Derivatives from Callistemon salignus.
复制标题
来自Callistemon Salignus的细胞毒性酰基氯醇葡萄醇衍生物。
DOI：
10.1007/s13659-017-0138-6
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发表时间：
2017-08
影响因子：
4.7
通讯作者：
Liu HY
中科院分区：
文献类型：
--
作者：
Qin XJ;Shu T;Yu Q;Yan H;Ni W;An LK;Li PP;Zhi YE;Khan A;Liu HY
从旗菜中分离到三种新的β-三酮和单萜萜类化合物Callisalignenes G-I(1-3)，以及两种已知的类似物（4和5）。通过核磁共振和质谱分析以及电子圆二色性（ECD）证据，明确了它们的结构和绝对构型。粘连烯H(2)和I(3)在C-7上有一个罕见的仲丁基部分。萜类化合物1-3对HCT116细胞具有细胞毒性，IC50值分别为8.51±1.8 μM、9.12±0.3 μM和16.33±3.3 μM。本文的在线版本（doi:10.1007/s13659-017-0138-6）包含补充材料，可供授权用户使用。
Callisalignenes G–I (1–3), three new meroterpenoids of β-triketone and monoterpene, along with two known analogues (4 and 5), were isolated from Callistemon salignus. Their structures and absolute configurations were unambiguously established by a combination of NMR and MS analysis and electronic circular dichroism (ECD) evidence. Callisalignenes H (2) and I (3) have a rare sec-butyl moiety at C-7. Meroterpenoids 1–3 exhibited cytotoxicity against HCT116 cells with IC50 values of 8.51 ± 1.8, 9.12 ± 0.3, and 16.33 ± 3.3 μM, respectively. Cytotoxic Acylphloroglucinol Derivatives from Callistemon salignus The online version of this article (doi:10.1007/s13659-017-0138-6) contains supplementary material, which is available to authorized users.