Role of microRNA in inner ear stem cells and related research progress.
Role of microRNA in inner ear stem cells and related research progress.
复制标题
microRNA在内耳干细胞中的作用及相关研究进展。
作者：
Xia Wu;Sheng-yu Zou;Fan Wu;Zuhong He;Weijia Kong
耳聋是严重影响人类生活质量的主要全球性健康问题之一。目前，对于耳蜗毛细胞（HC）损伤引起的耳聋还没有成功的治疗方法。哺乳动物听力损伤的不可逆性是内耳的感觉上皮不能通过自发再生来修复丢失的毛细胞和神经元。干细胞治疗感音神经性耳聋的目的是重建受损的内耳结构，实现功能性修复。microRNA（miRNA）是一类高度保守的内源性非编码小RNA，在耳蜗和毛细胞的发育过程中起着重要作用。miRNA还参与干细胞增殖和分化的调控，在内耳毛细胞再生过程中发挥重要作用，miRNA在听力损失的临床治疗中具有广阔的应用前景，有利于解决内耳毛细胞再生的医学难题。
Deafness is one of the major global health problems that seriously affects the quality of human life. At present, there are no successful treatments for deafness caused by cochlear hair cell (HC) damage. The irreversibility of mammalian hearing impairment is that the inner ear's sensory epithelium cannot repair lost hair cells and neurons through spontaneous regeneration. The goal of stem cell therapy for sensorineural hearing loss is to reconstruct the damaged inner ear structure and achieve functional repair. microRNA (miRNA), as a class of highly conserved endogenous non-coding small RNAs, plays an important role in the development of cochlea and HCs. miRNA also participates in the regulation of stem cell proliferation and differentiation, and plays an important role in the process of regeneration of inner ear HCs, miRNA has a broad application prospect of clinical treatment of hearing loss, which is conducive to solving the medical problem of inner ear HC regeneration.