Thalamic nuclei convey diverse contextual information to layer 1 of visual cortex.
Thalamic nuclei convey diverse contextual information to layer 1 of visual cortex.
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DOI：
10.1038/nn.4197
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发表时间：
2016-02
影响因子：
25
通讯作者：
Hofer SB
中科院分区：
文献类型：
--
作者：
Roth MM;Dahmen JC;Muir DR;Imhof F;Martini FJ;Hofer SB
感官知觉取决于刺激发生的背景。流行的模型强调大脑皮层反馈是语境调节的来源。然而，丘脑的高阶核团，如枕核，与许多皮质和皮质下区域相互连接，这表明丘脑在提供感觉和行为背景方面发挥了作用--然而，高阶丘脑向皮质传递的信号的性质仍然知之甚少。在这里，我们使用轴突钙成像来测量由小鼠脑枕等效体、外侧后核(Lp)以及背外侧膝状体(DLGN)提供给视觉皮质的信息。我们发现dLGN传递视网膜定位的精确视觉信号，而LP提供来自视觉场景的分布式信息。Lp和dLGN投影都携带运动信号。然而，虽然dLGN输入通常对跑步和视觉流动速度的积极组合做出反应，但LP信号显示自身产生的视觉运动和外部视觉运动之间的差异。因此，这个高阶丘脑核团传递不同的背景信号，告知视觉皮质动物自身行为无法预测的视觉场景变化。
Sensory perception depends on the context within which a stimulus occurs. Prevailing models emphasize cortical feedback as the source of contextual modulation. However, higher-order thalamic nuclei, such as the pulvinar, interconnect with many cortical and subcortical areas, suggesting a role for the thalamus in providing sensory and behavioral context – yet the nature of the signals conveyed to cortex by higher-order thalamus remains poorly understood. Here we use axonal calcium imaging to measure information provided to visual cortex by the pulvinar equivalent in mice, the lateral posterior nucleus (LP), as well as the dorsolateral geniculate nucleus (dLGN). We found that dLGN conveys retinotopically precise visual signals, while LP provides distributed information from the visual scene. Both LP and dLGN projections carry locomotion signals. However, while dLGN inputs often respond to positive combinations of running and visual flow speed, LP signals discrepancies between self-generated and external visual motion. This higher-order thalamic nucleus therefore conveys diverse contextual signals that inform visual cortex about visual scene changes not predicted by the animal’s own actions.