Dual effect of statin medication on the periodontium.
Dual effect of statin medication on the periodontium.
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他汀类药物对牙周组织的双重作用。
DOI：
10.1111/j.1600-051x.2009.01484.x
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发表时间：
2009
影响因子：
6.7
通讯作者：
P. Ylöstalo
中科院分区：
文献类型：
--
作者：
T. Saxlin;L. Suominen;M. Knuuttila;P. Alha;P. Ylöstalo
目的
本研究的目的是调查他汀类药物与成人牙周感染之间的关系。
材料和方法
这项研究是基于健康2000年调查的一个亚群，其中包括齿状非糖尿病，非风湿性受试者，不吸烟，年龄40-69岁（n=2032）。主要结果变量是牙周袋大于等于4 mm的牙齿数量。他汀类药物按两种方式分类：首先，接受某种他汀类药物治疗的受试者（n=134）与未接受任何他汀类药物治疗的受试者，其次，接受辛伐他汀（n=58）、阿托伐他汀（n =38）、其他一些他汀类药物（n=38）或未接受他汀类药物治疗的受试者。使用负二项和泊松回归模型估计相对风险（RR）。
结果
我们发现，他汀类药物和牙周感染的受试者与牙菌斑或牙龈出血之间的弱负相关。在没有牙龈出血的受试者中，发现他汀类药物与牙周袋加深的可能性增加有关。
结论
他汀类药物似乎对牙周组织有影响，这取决于牙周组织的炎症状况。需要更多的证据来全面了解他汀类药物的作用。
AIM
The aim of this study was to investigate the association between statin medication and periodontal infection in an adult population.
MATERIAL AND METHODS
The study was based on a subpopulation of the Health 2000 Survey, which included dentate non-diabetic, non-rheumatic subjects who did not smoke, aged 40-69 years (n=2032). The main outcome variable was the number of teeth with periodontal pockets of 4 mm or more. Statin medication was categorized in two ways: firstly, subjects with statin medication of some sort (n=134) versus those with none, and secondly, subjects taking either simvastatin (n=58), atorvastatin (n=38), some other statin (n=38) or no statin medication. Relative risks (RR) were estimated using negative binomial and Poisson regression models.
RESULTS
We found a weak negative association between statin medication and periodontal infection among subjects with dental plaque or gingival bleeding. Among subjects with no gingival bleeding, statin medication was found to be associated with an increased likelihood of having deepened periodontal pockets.
CONCLUSION
Statin medication appears to have an effect on the periodontium that is dependent on the inflammatory condition of the periodontium. More evidence is needed to achieve a comprehensive understanding of the effects of statins.