Melanocortin System in Kidney Homeostasis and Disease: Novel Therapeutic Opportunities.
Melanocortin System in Kidney Homeostasis and Disease: Novel Therapeutic Opportunities.
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肾脏稳态和疾病中的黑皮质素系统：新的治疗机会。
DOI：
10.3389/fphys.2021.651236
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发表时间：
2021
影响因子：
4
通讯作者：
Gong R
中科院分区：
文献类型：
--
作者：
Chang M;Chen B;Shaffner J;Dworkin LD;Gong R
黑素皮质素肽、黑素皮质素受体、黑素皮质素受体辅助蛋白和内源性黑素皮质素受体拮抗剂是构成黑素皮质素激素系统的关键成分，黑素皮质素激素系统是人体最复杂、最重要的激素系统之一。大量证据表明，黑素皮质素在啮齿类动物模型和人类患者的多种肾脏疾病中都具有保护作用。特别是类固醇生成的促肾上腺皮质激素（ACTH），已被证明在许多肾脏疾病中发挥有益作用，可能是通过独立于其类固醇生成活性的机制。在类固醇抵抗性肾病肾小球患者中，单药促肾上腺皮质激素治疗在诱导蛋白尿缓解方面仍然有效。这激发了对黑素皮质素系统在肾小球疾病中的潜在意义的研究。然而，我们对黑素皮质能通路在肾脏疾病中的作用的了解非常有限，仍有巨大的未知有待探索。其中最具争议的是肾脏中效应细胞的鉴定以及负责传递肾保护作用的黑素皮质素受体。本文综述了黑素皮质素激素系统，总结了黑素皮质素受体在肾脏中表达的现有证据，并对黑素皮质素治疗肾脏疾病的潜在策略进行了评价。
Melanocortin peptides, melanocortin receptors, melanocortin receptor accessory proteins, and endogenous antagonists of melanocortin receptors are the key components constituting the melanocortin hormone system, one of the most complex and important hormonal systems in our body. A plethora of evidence suggests that melanocortins possess a protective activity in a variety of kidney diseases in both rodent models and human patients. In particular, the steroidogenic melanocortin peptide adrenocorticotropic hormone (ACTH), has been shown to exert a beneficial effect in a number of kidney diseases, possibly via a mechanism independent of its steroidogenic activity. In patients with steroid-resistant nephrotic glomerulopathy, ACTH monotherapy is still effective in inducing proteinuria remission. This has inspired research on potential implications of the melanocortin system in glomerular diseases. However, our understanding of the role of the melanocortinergic pathway in kidney disease is very limited, and there are still huge unknowns to be explored. The most controversial among these is the identification of effector cells in the kidney as well as the melanocortin receptors responsible for conveying the renoprotective action. This review article introduces the melanocortin hormone system, summarizes the existing evidence for the expression of melanocortin receptors in the kidney, and evaluates the potential strategy of melanocortin therapy for kidney disease.
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影响因子：
13.6
作者：
Ghamari-Langroudi M;Cakir I;Lippert RN;Sweeney P;Litt MJ;Ellacott KLJ;Cone RD
通讯作者：
Cone RD
影响因子：
19.6
作者：
Deng, JP;Kohda, Y;Star, RA
通讯作者：
Star, RA
DOI：
10.1152/ajprenal.00231.2015
发表时间：
2016-05-01
影响因子：
4.2
作者：
Elvin, Johannes;Buvall, Lisa;Haraldsson, Borje
通讯作者：
Haraldsson, Borje
DOI：
10.1073/pnas.0809918106
发表时间：
2009-04-14
影响因子：
11.1
作者：
Chan, Li F.;Webb, Tom R.;Clark, Adrian J. L.
通讯作者：
Clark, Adrian J. L.
影响因子：
2.4
作者：
Gatti, Stefano;Colombo, Gualtiero;Catania, Anna
通讯作者：
Catania, Anna