Deep brain stimulation as a therapy for alcohol addiction.
Deep brain stimulation as a therapy for alcohol addiction.
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深部脑刺激作为酒精成瘾的治疗方法
DOI：
10.1007/7854_2012_207
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发表时间：
2013
影响因子：
--
通讯作者：
Visser-Vandewalle V
中科院分区：
文献类型：
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作者：
Münte TF;Heinze HJ;Visser-Vandewalle V
脑深部电刺激（DBS）已被牢固确立为运动障碍的治疗方法。最近，来自病例报告和小型病例系列的证据也表明DBS对精神疾病（包括成瘾）有效。本文综述了DBS治疗成瘾的原理和可能靶点的选择。然后，我们考虑来自动物模型以及人类案例研究的证据。我们的结论是，DBS，特别是脑桥核（NAcc）是一个有前途的治疗选择，值得进一步研究。
Deep brain stimulation (DBS) has been firmly established as a therapy for movement disorders. Recently, evidence from case reports and small case series also suggests DBS to be effective in psychiatric disorders including addiction. Here we review the rationale of DBS in addiction and the selection of possible targets. We then consider evidence from animal models as well as human case studies. We conclude that DBS in particular of the nucleus accumbens (NAcc) represents a promising treatment option in addiction which deserves further investigation.