Effect of fermented papaya preparation on dermal and intestinal mucosal immunity and allergic inflammations
Effect of fermented papaya preparation on dermal and intestinal mucosal immunity and allergic inflammations
复制标题
DOI：
10.1002/jsfa.3190
复制
发表时间：
2008-05-01
影响因子：
4.1
通讯作者：
Mori, Akitane
中科院分区：
文献类型：
--
作者：
Hiramoto, Keiichi;Imao, Mitsuko;Mori, Akitane
背景技术背景：由木瓜酵母发酵而成的发酵木瓜制剂（FPP）是一种天然保健食品，在日本有商业销售。先前的研究表明，FPP具有抗氧化活性。然而，FPP对过敏性疾病的影响仍不清楚。本工作的目的是检查是否口服给药FPP小鼠抑制两种类型的接触性超敏反应模型，FITC（Th 2型）诱导的耳朵和结肠水肿，恶唑酮（Th 1型）诱导的耳朵和结肠oedema.RESULTS：FITC或恶唑酮的致敏增加IL-10，IFN-γ，和TNF-α的血浆水平。组织学检查显示结肠中伊加、树突状细胞和炎性细胞显著增加。当动物在用FITC或恶唑酮致敏前给予FPP时，由FITC或恶唑酮引起的所有事件均显着减少。结论：这些结果表明，口服FPP可能具有预防接触性超敏免疫反应的治疗潜力。(C)2008化学工业协会。
BACKGROUND: Fermented papaya preparation (FPP) from yeast fermentation of Carica papaya Linn is a natural health food that is commercially sold in Japan. A previous study revealed that FPP has antioxidant activity. However, the effect of FPP on allergic diseases remains unclear. The aim of the present work was to examine whether the oral administration of FPP to mice restrained two types of contact hypersensitivity models, FITC (Th2 type) induced ear and colon oedema, and oxazolone (Th1 type) induced ear and colon oedema.RESULTS: The sensitisation of FITC or oxazolone increased the plasma levels of IL-10, IFN-gamma, and TNF-alpha. Histological examinations revealed a marked increase of IgA, dendritic cells and inflammatory cells in the colon. When the animals were given FPP before sensitisation by FITC or oxazolone, all the events induced by either FITC or oxazolone decreased markedly.CONCLUSION: These results suggest that the oral administration of the FPP may have a therapeutic potential for the prevention of contact hypersensitive immuno-response. (C) 2008 Society of Chemical Industry.