Prolonged response to succinylcholine: a new variant of plasma cholinesterase that is identified as normal by traditional phenotyping methods.
Prolonged response to succinylcholine: a new variant of plasma cholinesterase that is identified as normal by traditional phenotyping methods.
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对琥珀胆碱的延长反应：血浆胆碱酯酶的一种新变体，通过传统表型分析方法被鉴定为正常。
DOI：
10.1097/00000539-199508000-00039
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发表时间：
1995
影响因子：
5.7
通讯作者：
laDu,BN
中科院分区：
文献类型：
--
作者：
Greenberg,CP;Primo-Parmo,SL;Pantuck,EJ;laDu,BN
人血浆胆碱酯酶（丁酰胆碱酯酶、假胆碱酯酶）的一些遗传变异（丁酰胆碱酯酶、假胆碱酯酶）对琥珀酰胆碱的亲和力降低（非典型变异和耐氟化物变异），可通过其对地布卡因和氟化物等差异抑制剂的反应来识别，而其他变异（沉默变异）则被检测为完全或几乎完全缺乏血浆胆碱酯酶活性 (1, 2)。由于测定琥珀酰胆碱水解的技术困难，苯甲酰胆碱、丁酰硫代胆碱或其他硫酯通常在这些测试中用作替代底物。实验室结果表明血浆胆碱酯酶活性和类型正常的患者对琥珀胆碱的反应延长的报告长期以来表明存在这种酶的一种或多种变体，这些变体水解琥珀胆碱的能力降低，但水解常规使用的替代底物的能力正常，并且对常规使用的差异抑制剂具有正常的耐药性 (3-5)。这里报告了这样的变体。
S ome of the genetic variants of human plasma cholinesterase (butyrylcholinesterase, pseudocholinesterase) with reduced affinities for succinylcholine(the atypical and fluoride-resistant variants) are recognized by their response to differential inhibitors such as dibucaine and fluoride, while others (the silent variants) are detected as a complete or nearly complete absence of plasma cholinesterase activity (1, 2). Because of technical difficulties in assaying succinylcholine hydrolysis, benzoylcholine, butyrylthiocholine, or other thioesters are usually employed as surrogate substrates in these tests. Reports of prolonged response to succinylcholine in patients whose laboratory results indicate normal plasma cholinesterase activity and type have long suggested the existence of one or more variants of this enzyme that have a decreased capacity to hydrolyze succinylcholine but a normal ability to hydrolyze the conventionally used surrogate substrates and a normal resistance to the conventionally used differential inhibitors (3-5). Such a variant is reported here.
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影响因子：
9.8
作者：
C. P. Nogueira;C. Bartels;I. M. C. McGuire;S. Adkins;T. Lubrano;M. Herbert;Rubinstein;H. Lightstone;A. Spek;O. Lockridge;B. Du
通讯作者：
C. P. Nogueira;C. Bartels;I. M. C. McGuire;S. Adkins;T. Lubrano;M. Herbert;Rubinstein;H. Lightstone;A. Spek;O. Lockridge;B. Du
正常基因型患者的长期神经肌肉阻滞
影响因子：
10.7
作者：
S. Cherala
通讯作者：
S. Cherala
血浆胆碱酯酶：基因和变异
影响因子：
5.7
作者：
E. Pantuck
通讯作者：
E. Pantuck
假胆碱酯酶变异。
DOI：
10.1007/978-3-642-67179-1_7
发表时间：
1978
期刊：
Human genetics. Supplement
影响因子：
--
作者：
H. Goedde;D. Agarwal
通讯作者：
D. Agarwal
正常基因型患者服用琥珀胆碱后出现长期神经肌肉阻滞
影响因子：
10.7
作者：
D. Sapsford;G. Bush
通讯作者：
G. Bush