Bone Density and Fractures in HIV-infected Postmenopausal Women: A Systematic Review.
Bone Density and Fractures in HIV-infected Postmenopausal Women: A Systematic Review.
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DOI：
10.1016/j.jana.2015.03.005
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发表时间：
2015-07
期刊：
影响因子：
--
通讯作者：
Reame NK
中科院分区：
文献类型：
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作者：
Cortés YI;Yin MT;Reame NK
随着有效的抗逆转录病毒疗法的发展，感染艾滋病毒的妇女寿命延长，并过渡到更年期。我们研究的目的是系统地检查绝经是HIV感染妇女骨质疏松症和骨折的额外风险预测因子的证据。在电子数据库中检索HIV感染的绝经后妇女的低骨密度或骨折研究。使用经验证的质量评估工具对符合纳入标准的研究（n = 10）进行评价。大多数研究被评为高质量，其余为一般。这些研究中报告的骨质疏松症患病率在HIV感染和未感染的绝经后妇女中分别为7.3%至84%和0.7%至23%。在两项资格研究中，绝经后状态不是HIV感染妇女骨折的预测因素。研究结果表明，艾滋病护理人员应准确评估绝经后状态和可改变的风险因素骨质疏松症在所有老年艾滋病感染妇女。
With the development of effective antiretroviral therapy, HIV-infected women are living longer and transitioning through menopause. The purpose of our study was to systematically examine the evidence that menopause is an additional risk predictor for osteoporosis and fractures in HIV-infected women. Electronic databases were searched for studies of low bone density or fractures in HIV-infected postmenopausal women. Studies that met the inclusion criteria (n = 10) were appraised using a validated quality assessment tool. The majority of studies were rated as good quality and the remaining were fair. The prevalence of osteoporosis reported in these studies ranged from 7.3% to 84% and 0.7% to 23% in HIV-infected and uninfected postmenopausal women, respectively. In the two qualifying studies, postmenopausal status was not a predictor of fractures in HIV-infected women. Findings suggest that HIV care providers should accurately assess postmenopausal status and modifiable risk factors for osteoporosis in all older HIV-infected women.