Post-transcriptional gene silencing across kingdoms
Post-transcriptional gene silencing across kingdoms
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DOI：
10.1016/s0959-437x(00)00134-9
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发表时间：
2000-12-01
影响因子：
4
通讯作者：
Macino, G
中科院分区：
文献类型：
--
作者：
Cogoni, C;Macino, G
转录后基因沉默（PTGS）作为转基因或双链RNA分子导入的结果已被发现发生在许多物种中。在过去的一年里，在不同系统中的研究大大提高了我们对这些现象的分子机制的理解。PTGS在植物和动物王国中的普遍存在以及共同遗传机制的发现表明，PTGS是一种通用的基因调控系统，在生物过程中至关重要，如保护免受病毒和转座子的侵害。
Post-transcriptional gene silencing (PTGS) as a consequence of the introduction of either transgenes or double-stranded RNA molecules has been found to occur in a number of species. In the past year, studies in different systems have greatly enhanced our understanding of the molecular mechanisms of these phenomena. The ubiquitous presence of PTGS in both the plant and animal kingdoms and the finding of common genetic mechanisms suggest that PTGS is a universal gene-regulation system fundamental in biological processes such as protection against viruses and transposons.